Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 7/20 | 0.67 |
| ▸ | EGFR | P00533 | 6/20 | 0.52 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 5/20 | 0.43 |
| ▸ | RET | P07949 | 4/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.43 |
| ▸ | KIF5B | P33176 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL371765 | 0.84 | KIT (0.67) | KITEGFRTRPA1PDE10AKDR | |
| SCHEMBL15504611 | 0.81 | KIT (1.00) | KITEGFRTRPA1KDRRET | |
| SCHEMBL8172203 | 0.79 | KIT (0.59) | KITEGFRKDRRET | |
| SCHEMBL15516134 | 0.78 | KIT (1.00) | KITEGFRTRPA1KDRRET | |
| SCHEMBL7714348 | 0.76 | KIT (0.74) | KITEGFRTRPA1PDE10AKDR | |
| SCHEMBL5665515 | 0.75 | KIT (0.58) | KITEGFRKDRRETKIF5B | |
| SCHEMBL4974935 | 0.75 | KIT (0.58) | KITEGFRKDRRETFLT1 | |
| SCHEMBL1264612 | 0.74 | KIT (0.60) | KITEGFRTRPA1PDE10AKDR | |
| SCHEMBL6182709 | 0.73 | KIT (0.59) | KITEGFRKDRRET | |
| SCHEMBL5569432 | 0.72 | KIT (0.69) | KITEGFRKDRRETFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2213661-A1 | c-Met Modulators and Methods of Use | Exelixis Inc. (US) | 2010-08-04 | — | — | EP | disclosed |
| EP-2210607-A1 | N-[3-fluoro-4-({6-(methyloxy)-7-[(3-piperidin-1-ylpropyl)oxy]quinolin-4-yl}oxy)phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide for the treatment of cancer | Exelixis Inc. (US) | 2010-07-28 | — | — | EP | disclosed |