Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 11/20 | 0.74 |
| ▸ | EGFR | P00533 | 6/20 | 0.54 |
| ▸ | KDR | P35968 | 2/20 | 0.54 |
| ▸ | LCK | P06239 | 2/20 | 0.50 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.49 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15504611 | 0.85 | KIT (1.00) | KITEGFRKDRTRPA1 | |
| SCHEMBL15665140 | 0.78 | KIT (1.00) | KIT | |
| SCHEMBL2926080 | 0.76 | KIT (0.67) | KITEGFRKDRTRPA1PDE10A | |
| SCHEMBL1264612 | 0.76 | KIT (0.60) | KITEGFRKDRLCKTRPA1 | |
| SCHEMBL6182448 | 0.75 | KIT (0.78) | KITEGFRKDRTRPA1 | |
| SCHEMBL15664429 | 0.74 | KIT (1.00) | KIT | |
| SCHEMBL15664700 | 0.74 | KIT (1.00) | KIT | |
| SCHEMBL17780990 | 0.74 | AMY1A (0.52) | KITEGFRTRPA1 | |
| SCHEMBL15665218 | 0.73 | KIT (1.00) | KIT | |
| SCHEMBL6836832 | 0.72 | EGFR (0.62) | KITEGFRKDRLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE37650-E1 | Aryl and heteroaryl quinazoline compounds which inhibit CSF-1R receptor tyrosine kinase | AVENTIS PHARMACETICAL PRODUCTS, INC. | 2002-04-09 | — | — | US | claimed |