Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 13/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CCR2 | P41597 | 1/20 | 0.33 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9947945 | 0.96 | PTGER4 (0.46) | PTGER4CYP1A2CYP2D6KDM4EALDH1A1 | |
| SCHEMBL4610415 | 0.96 | PTGER4 (0.46) | PTGER4CYP1A2CYP2D6KDM4EALDH1A1 | |
| SCHEMBL10058511 | 0.91 | PTGER4 (0.47) | PTGER4CYP1A2CYP2D6KDM4EALDH1A1 | |
| SCHEMBL1590622 | 0.91 | PTGER4 (0.47) | PTGER4CYP1A2CYP2D6KDM4EALDH1A1 | |
| SCHEMBL13177487 | 0.89 | PTGER4 (0.43) | PTGER4CYP1A2CYP2D6KDM4EALDH1A1 | |
| SCHEMBL8516039 | 0.89 | PTGER4 (0.49) | PTGER4CYP1A2CYP2D6KDM4EALDH1A1 | |
| SCHEMBL2924739 | 0.89 | PTGER4 (0.49) | PTGER4CYP1A2CYP2D6KDM4EALDH1A1 | |
| SCHEMBL9948176 | 0.86 | PTGER4 (0.56) | PTGER4CYP1A2CYP2D6 | |
| SCHEMBL9947715 | 0.86 | PTGER4 (0.58) | PTGER4CYP1A2CYP2D6 | |
| SCHEMBL9948183 | 0.86 | PTGER4 (0.47) | PTGER4CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2081897-B1 | ISOINDOL DERIVATIVES AS EP4 RECEPTOR AGONISTS | GLAXO GROUP LTD (GB) | 2010-09-15 | — | — | EP | disclosed |
| US-20100076048-A1 | Isoindol Derivatives As EP4 Receptor Agonists | GLAXO GROUP LIMITED (GB) | 2010-03-25 | — | — | US | disclosed |
| EP-2081897-A1 | ISOINDOL DERIVATIVES AS EP4 RECEPTOR AGONISTS | Glaxo Group Limited (GB) | 2009-07-29 | — | — | EP | disclosed |
| WO-2008046798-A1 | ISOINDOL DERIVATIVES AS EP4 RECEPTOR AGONISTS | GLAXO GROUP LIMITED (GB) | 2008-04-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100076048-A1 | Isoindol Derivatives As EP4 Receptor Agonists | PTGER4, PTGER1, PTGER3 | PTGER4 1/4885CYP1A2 218/4885CYP2D6 304/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.