Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 15/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | THRA | P10827 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9947945 | 1.00 | PTGER4 (0.46) | PTGER4CYP1A2CYP2D6THRATHRB | |
| SCHEMBL10058511 | 0.96 | PTGER4 (0.47) | PTGER4CYP1A2CYP2D6THRATHRB | |
| SCHEMBL2926089 | 0.96 | PTGER4 (0.49) | PTGER4CYP1A2CYP2D6KDM4EALDH1A1 | |
| SCHEMBL1590622 | 0.96 | PTGER4 (0.47) | PTGER4CYP1A2CYP2D6THRATHRB | |
| SCHEMBL9948176 | 0.91 | PTGER4 (0.56) | PTGER4CYP1A2CYP2D6 | |
| SCHEMBL9947715 | 0.91 | PTGER4 (0.58) | PTGER4CYP1A2CYP2D6 | |
| SCHEMBL9947714 | 0.91 | PTGER4 (0.47) | PTGER4CYP1A2CYP2D6 | |
| SCHEMBL9948183 | 0.91 | PTGER4 (0.47) | PTGER4CYP1A2CYP2D6 | |
| SCHEMBL10058567 | 0.90 | PTGER4 (0.40) | PTGER4KDM4EALDH1A1HPGDMDM2 | |
| SCHEMBL10058566 | 0.90 | PTGER4 (0.40) | PTGER4KDM4EALDH1A1HPGDMDM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979317-B1 | BENZOISOINDOLE DERIVATIVES FOR THE TREATMENT OF PAIN | GLAXO GROUP LTD (GB) | 2012-08-22 | — | — | EP | disclosed |
| US-8207213-B2 | Benzoisoindole derivatives for the treatment of pain | GLAXO GROUP LIMITED (GB) | 2012-06-26 | — | — | US | disclosed |
| EP-1979317-A1 | BENZOISOINDOLE DERIVATIVES FOR THE TREATMENT OF PAIN | GLAXO GROUP LIMITED (GB) | 2008-10-15 | — | — | EP | disclosed |
| WO-2007088189-A1 | BENZOISOINDOLE DERIVATIVES FOR THE TREATMENT OF PAIN | GLAXO GROUP LIMITED (GB) | 2007-08-09 | — | — | WO | disclosed |