Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN1A | P35498 | 4/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 4/20 | 0.41 |
| ▸ | SCN8A | Q9UQD0 | 4/20 | 0.41 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.37 |
| ▸ | GBA1 | P04062 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | BRS3 | P32247 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | FADS1 | O60427 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1615546 | 1.00 | SCN1A (0.41) | SCN1ASCN5ASCN8APFKFB3GBA1 | |
| SCHEMBL1616498 | 0.95 | PFKFB3 (0.44) | SCN1ASCN5ASCN8APFKFB3GBA1 | |
| SCHEMBL1616265 | 0.93 | SCN1A (0.41) | SCN1ASCN5ASCN8APFKFB3GBA1 | |
| SCHEMBL2919481 | 0.93 | SCN1A (0.41) | SCN1ASCN5ASCN8APFKFB3GBA1 | |
| SCHEMBL1616346 | 0.92 | MEN1 (0.46) | SCN1ASCN5ASCN8APFKFB3GBA1 | |
| SCHEMBL1615576 | 0.86 | CA1 (0.38) | PFKFB3MAPTMEN1ALDH1A1KMT2A | |
| SCHEMBL1615372 | 0.85 | PKM (0.39) | MAPTALDH1A1KMT2AKDM4EGAA | |
| SCHEMBL1616597 | 0.84 | MAP2K4 (0.38) | PFKFB3MAPTMEN1ALDH1A1KMT2A | |
| SCHEMBL1615436 | 0.83 | MAPT (0.36) | MAPTMEN1ALDH1A1KMT2AGAA | |
| SCHEMBL1616691 | 0.83 | PFKFB3 (0.39) | SCN1ASCN5ASCN8APFKFB3GBA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2099763-B1 | 2-AMINOQUINOLINES AS 5-HT(5A) RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-08-11 | — | — | EP | disclosed |