Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 1/20 | 0.36 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 6/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | BRD2 | P25440 | 1/20 | 0.33 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.33 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.33 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3665535 | 0.83 | GRIA1 (0.41) | GRIA1GRIA3PDE4DGLAKDM4E | |
| SCHEMBL1891956 | 0.72 | GRIA1 (0.70) | GRIA1GRIA3PDE4DGLAKDM4E | |
| SCHEMBL1882179 | 0.69 | GRIA1 (0.59) | GRIA1GRIA3PDE4DGRM5MAPT | |
| Water SCHEMBL4777578 | 0.67 | GRIA1 (0.56) | GRIA1GRIA3PDE4DGRM5 | |
| SCHEMBL2918046 | 0.67 | GRIA1 (0.56) | GRIA1GRIA3PDE4DGRM5 | |
| SCHEMBL2926367 | 0.67 | GRIA1 (0.44) | GRIA1GRIA3PDE4DGLAKDM4E | |
| SCHEMBL3668801 | 0.66 | GRIA1 (0.45) | GRIA1GRIA3PDE4DGRM5 | |
| SCHEMBL4779376 | 0.65 | CYP2A6 (0.42) | GLAKDM4EALDH1A1GAAHPGD | |
| SCHEMBL5534283 | 0.65 | KDM4E (0.43) | GLAKDM4EALDH1A1HCRTR1GAA | |
| SCHEMBL3665537 | 0.65 | SMN1; SMN2 (0.35) | GRIA1GRIA3PDE4DGLAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222296-A2 | AMPA RECEPTOR ANTAGONISTS AND ZONISAMIDE FOR EPILEPSY | Eisai R&D Management Co., Ltd. (JP) | 2010-09-01 | — | — | EP | disclosed |
| WO-2009082038-A2 | AMPA RECEPTOR ANTAGONISTS AND ZONISAMIDE FOR EPILEPSY | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2009-07-02 | — | — | WO | disclosed |