Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 1/20 | 0.44 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | PRKDC | P78527 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 5/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3665535 | 0.73 | GRIA1 (0.41) | GRIA1GRIA3PDE4DGRM5SCN9A | |
| SCHEMBL1891956 | 0.71 | GRIA1 (0.70) | GRIA1GRIA3PDE4DGRM5GLA | |
| SCHEMBL18411434 | 0.68 | GRIA1 (0.53) | GRIA1GRIA3PDE4DGRM5ALDH1A1 | |
| SCHEMBL3671757 | 0.68 | KMT2A (0.35) | GRIA1GRIA3PDE4DGLAKDM4E | |
| SCHEMBL1882179 | 0.68 | GRIA1 (0.59) | GRIA1GRIA3PDE4DGRM5 | |
| SCHEMBL18411316 | 0.67 | GRIA1 (0.52) | GRIA1GRIA3PDE4DGRM5ALDH1A1 | |
| SCHEMBL17426491 | 0.67 | KDM4E (0.52) | PRKDCGRM5GLALMNAKDM4E | |
| SCHEMBL2926372 | 0.67 | GRIA1 (0.36) | GRIA1GRIA3PDE4DGRM5SCN9A | |
| SCHEMBL18411436 | 0.65 | GRIA1 (0.47) | GRIA1GRIA3PDE4DGRM5GLA | |
| SCHEMBL18411446 | 0.64 | GRIA1 (0.46) | GRIA1GRIA3PDE4DGRM5GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222296-A2 | AMPA RECEPTOR ANTAGONISTS AND ZONISAMIDE FOR EPILEPSY | Eisai R&D Management Co., Ltd. (JP) | 2010-09-01 | — | — | EP | disclosed |
| WO-2009082038-A2 | AMPA RECEPTOR ANTAGONISTS AND ZONISAMIDE FOR EPILEPSY | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2009-07-02 | — | — | WO | disclosed |