Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 3/20 | 0.41 |
| ▸ | CA12 | O43570 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30380364 | 1.00 | DRD2 (0.44) | DRD2TDP1BRD4CA12CA1 | |
| SCHEMBL29265250 | 1.00 | DRD2 (0.44) | DRD2TDP1BRD4CA12CA1 | |
| SCHEMBL31376155 | 0.99 | DRD2 (0.43) | DRD2TDP1BRD4CA12CA1 | |
| SCHEMBL29265374 | 0.96 | DRD2 (0.42) | DRD2TDP1BRD4CA12CA1 | |
| SCHEMBL30380512 | 0.89 | DRD2 (0.51) | DRD2SMN1; SMN2 | |
| SCHEMBL25405883 | 0.88 | BRD4 (0.43) | DRD2TDP1BRD4CA12CA1 | |
| SCHEMBL29265376 | 0.86 | TDP1 (0.43) | DRD2TDP1BRD4CA12CA1 | |
| SCHEMBL29265249 | 0.84 | BRD4 (0.42) | DRD2TDP1BRD4CA12CA1 | |
| SCHEMBL25014531 | 0.84 | DRD2 (0.47) | DRD2TDP1BRD4CA12CA1 | |
| SCHEMBL25014517 | 0.84 | DRD2 (0.47) | DRD2TDP1BRD4CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4380937-A1 | CONJUGATES COMPRISING COVALENT BINDERS FOR TARGETING INTRACELLULAR PROTEINS | Rayzebio, Inc. (US) | 2024-06-12 | — | — | EP | disclosed |
| CN-118176194-A | Conjugates comprising covalent binding agents for targeting intracellular proteins | 瑞择生物公司 | 2024-06-11 | — | — | CN | disclosed |
| WO-2023014988-A1 | CONJUGATES COMPRISING COVALENT BINDERS FOR TARGETING INTRACELLULAR PROTEINS | RAYZEBIO, INC. (US) | 2023-02-09 | — | — | WO | disclosed |