Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | GBA1 | P04062 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29270801 | 0.91 | LMNA (0.35) | TP53LMNAHDAC1HDAC8HDAC6 | |
| SCHEMBL29270754 | 0.85 | AKR1B1 (0.32) | LMNA | |
| SCHEMBL29270822 | 0.79 | PLAT (0.30) | — | |
| SCHEMBL29270724 | 0.78 | SSTR4 (0.36) | TP53LMNAHDAC1HDAC8HDAC6 | |
| SCHEMBL29270742 | 0.78 | HDAC1 (0.41) | LMNAHDAC1HDAC8HDAC6POLB | |
| SCHEMBL29270820 | 0.75 | HDAC1 (0.33) | HDAC1HDAC8HDAC6 | |
| SCHEMBL29270794 | 0.75 | HDAC1 (0.39) | LMNAHDAC1HDAC8HDAC6POLB | |
| SCHEMBL29270739 | 0.75 | — | — | |
| SCHEMBL29270810 | 0.73 | TP53 (0.35) | TP53LMNAHDAC1HDAC8HDAC6 | |
| SCHEMBL29796701 | 0.72 | GAA (0.41) | HDAC1HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116964048-A | Bicyclic tetrahydroazepine derivatives for the treatment of cancer | 豪夫迈·罗氏有限公司 | 2023-10-27 | — | — | CN | disclosed |