SCHEMBL29280470

SCHEMBL29280470

N#COC(=O)c1ccc(C(=O)OC#N)cc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 6/20 0.39
CA2 P00918 6/20 0.39
CA12 O43570 3/20 0.39
CA7 P43166 3/20 0.39
CA9 Q16790 3/20 0.39
CA14 Q9ULX7 3/20 0.39
TDP1 Q9NUW8 1/20 0.39
F2 P00734 1/20 0.39
LMNA P02545 1/20 0.39
TSHR P16473 2/20 0.36
ALDH1A1 P00352 1/20 0.35
MAPT P10636 1/20 0.35
MEN1 O00255 1/20 0.35
KMT2A Q03164 1/20 0.35
ESR1 P03372 1/20 0.35
ESR2 Q92731 1/20 0.35
PARP15 Q460N3 1/20 0.35
PARP10 Q53GL7 1/20 0.35
PARP2 Q9UGN5 1/20 0.35
TP53 P04637 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27817073 0.89 TDP1 (0.57) TDP1LMNAALDH1A1MAPTMEN1
SCHEMBL3870676 0.88 LMNA (0.56) TDP1F2LMNATSHRALDH1A1
SCHEMBL31190194 0.85 PDCD1 (0.53) F2LMNAMAPT
SCHEMBL17101824 0.85 CA1 (0.62) CA1CA2LMNAMAPTMEN1
SCHEMBL25373730 0.84 HSD17B10 (0.53) LMNATSHRALDH1A1MEN1KMT2A
SCHEMBL16193048 0.84 TDP1 (0.52) TDP1LMNAALDH1A1MAPTMEN1
SCHEMBL27289934 0.77 CA12 (0.30) CA1CA2CA12CA7CA9
SCHEMBL28878896 0.75 NPC1 (0.45) TDP1F2LMNATSHRALDH1A1
SCHEMBL6384522 0.75 TPMT (0.46) CA1CA2CA12CA7CA9
SCHEMBL28169744 0.75 POLB (0.55) CA1CA2CA12CA7CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110770230-B Production of trimethylbenzene derivatives 罗地亚经营管理公司 2024-03-26 CN disclosed