Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 13/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1119602 | 0.77 | SYK (0.37) | HRH3SYKKCNH2HRH4SMN1; SMN2 | |
| SCHEMBL8002972 | 0.71 | HRH3 (0.38) | TLR8HRH3SYKKCNH2HRH4 | |
| Hydrochloric Acid SCHEMBL1961301 | 0.70 | HRH3 (0.37) | TLR8HRH3SYKKCNH2HRH4 | |
| SCHEMBL17827097 | 0.70 | TKT (0.43) | TLR8 | |
| SCHEMBL3599527 | 0.69 | HRH3 (0.38) | HRH3HRH4 | |
| SCHEMBL3613321 | 0.68 | KDM4E (0.46) | KCNH2SMN1; SMN2 | |
| SCHEMBL3608725 | 0.68 | ALDH1A1 (0.40) | SYKKCNH2 | |
| Hydrochloric Acid SCHEMBL1119496 | 0.68 | HRH3 (0.37) | HRH3HRH4 | |
| SCHEMBL15652833 | 0.68 | KDM4C (0.48) | HRH3SYKKCNH2HRH4 | |
| SCHEMBL1119535 | 0.67 | HRH3 (0.41) | HRH3SYKKCNH2HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229392-A1 | TRIAZOLOTRIAZINES AND TRIAZOLOPYRAZINES AND THEIR USE AS GSK3BETA INHIBITORS | Bayer Schering Pharma Aktiengesellschaft (DE) | 2010-09-22 | — | — | EP | disclosed |
| WO-2009074259-A1 | TRIAZOLOTRIAZINES AND TRIAZOLOPYRAZINES AND THE USE THEREOF | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2009-06-18 | — | — | WO | disclosed |