Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 10/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | TTK | P33981 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2927992 | 0.96 | ALDH1A1 (0.40) | PTK2LRRK2ALDH1A1HPGDTSHR | |
| SCHEMBL13515312 | 0.90 | KDR (0.46) | PTK2LRRK2ALDH1A1HPGDTSHR | |
| SCHEMBL2932358 | 0.87 | IGF1R (0.39) | PTK2LRRK2ALDH1A1HPGDTSHR | |
| SCHEMBL4244323 | 0.87 | PTK2 (0.39) | PTK2LRRK2ALDH1A1HPGDTSHR | |
| SCHEMBL2928408 | 0.86 | PIM3 (0.46) | LRRK2CCNA2CDK2TTKAURKA | |
| Trifluoroacetic Acid SCHEMBL2960848 | 0.86 | TMEM97 (0.40) | PTK2LRRK2CCNA2CDK2 | |
| Trifluoroacetic Acid SCHEMBL2927143 | 0.85 | KDR (0.45) | PTK2LRRK2ALDH1A1HPGDTSHR | |
| SCHEMBL2935096 | 0.84 | ADORA2A (0.38) | PTK2LRRK2CCNA2CDK2TTK | |
| Trifluoroacetic Acid SCHEMBL2928635 | 0.83 | DYRK1A (0.47) | LRRK2TTK | |
| SCHEMBL2936399 | 0.82 | CCNA2 (0.36) | PTK2LRRK2CCNA2CDK2TTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044051-B1 | PYRIDINE AND PYRAZINE DERIVATIVES AS MNK KINASE INHIBITORS | BIOVITRUM AB PUBL (SE) | 2010-01-27 | — | — | EP | disclosed |