Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 2/20 | 0.34 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | CPA1 | P15085 | 1/20 | 0.33 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27726493 | 0.96 | GRIK1 (0.32) | GRIK1GRIK2CYP2C19CPA1 | |
| SCHEMBL5132469 | 0.84 | GRIK1 (0.35) | GRIK1GRIK2CYP2C19CPA1ABCC4 | |
| SCHEMBL28407507 | 0.78 | TSHR (0.38) | GRIK1GRIK2 | |
| SCHEMBL10921623 | 0.78 | TSHR (0.37) | GRIK1GRIK2MAPT | |
| SCHEMBL5040922 | 0.78 | GRIK1 (0.32) | GRIK1GRIK2CYP2C19CPA1ABCC4 | |
| SCHEMBL4858035 | 0.77 | — | — | |
| SCHEMBL8731071 | 0.77 | — | — | |
| SCHEMBL9679700 | 0.76 | ABCC4 (0.38) | GRIK1GRIK2CYP2C19CPA1ABCC4 | |
| SCHEMBL449909 | 0.76 | HCAR2 (0.47) | GRIK1GRIK2CYP2C19CPA1ABCC4 | |
| SCHEMBL11130915 | 0.76 | TSHR (0.37) | GRIK1GRIK2CYP2C19CPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109301326-A | A kind of electrolyte and electrochemical appliance | 宁德新能源科技有限公司 | 2019-02-01 | — | — | CN | disclosed |