Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | MGAM | O43451 | 2/20 | 0.39 |
| ▸ | RAD52 | P43351 | 1/20 | 0.37 |
| ▸ | BAX | Q07812 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18982022 | 1.00 | LMNA (0.44) | LMNAL3MBTL1TDP1SMN1; SMN2MAPT | |
| Hydrochloric Acid SCHEMBL27086657 | 0.98 | SMN1; SMN2 (0.45) | LMNAL3MBTL1TDP1SMN1; SMN2MAPT | |
| Hydrochloric Acid SCHEMBL27086652 | 0.98 | SMN1; SMN2 (0.45) | LMNAL3MBTL1TDP1SMN1; SMN2MAPT | |
| SCHEMBL11671702 | 0.81 | KDM4E (0.38) | LMNAL3MBTL1TDP1SMN1; SMN2MAPT | |
| SCHEMBL1361161 | 0.81 | MAPT (0.64) | LMNASMN1; SMN2MAPTATMRAD52 | |
| SCHEMBL4400918 | 0.81 | MAPT (0.64) | LMNASMN1; SMN2MAPTATMRAD52 | |
| SCHEMBL16908299 | 0.81 | MAPT (0.64) | LMNASMN1; SMN2MAPTATMRAD52 | |
| SCHEMBL19000300 | 0.79 | ATM (0.61) | LMNAL3MBTL1TDP1MAPTATM | |
| SCHEMBL15553304 | 0.79 | MAPT (0.61) | LMNAL3MBTL1SMN1; SMN2MAPTATM | |
| SCHEMBL21757993 | 0.79 | MAPT (0.61) | LMNASMN1; SMN2MAPTATMRAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108699028-B | Substituted 4-phenylpyridines as non-systemic TGR5 agonists | 阿德利克斯公司 | 2021-10-22 | — | — | CN | disclosed |