Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Ethylparaben. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.69 |
| ▸ | CA12 | O43570 | 6/20 | 0.96 |
| ▸ | CA1 | P00915 | 6/20 | 0.96 |
| ▸ | CA2 | P00918 | 6/20 | 0.96 |
| ▸ | CA7 | P43166 | 6/20 | 0.96 |
| ▸ | CA9 | Q16790 | 6/20 | 0.96 |
| ▸ | CA14 | Q9ULX7 | 6/20 | 0.96 |
| ▸ | ESR1 | P03372 | 3/20 | 0.96 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.96 |
| ▸ | TSHR | P16473 | 2/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.69 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.69 |
| ▸ | KDR | P35968 | 1/20 | 0.69 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.69 |
| ▸ | LMNA | P02545 | 3/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.66 |
| ▸ | MAOA | P21397 | 1/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethylparaben SCHEMBL28368 | 0.98 | CA12 (1.00) | CA12CA1CA2CA7CA9 | |
| Ethylparaben SCHEMBL5311680 | 0.98 | CA12 (1.00) | CA12CA1CA2CA7CA9 | |
| Ethylparaben SCHEMBL29810737 | 0.96 | CA12 (0.96) | CA12CA1CA2CA7CA9 | |
| Ethylparaben SCHEMBL475792 | 0.96 | CA12 (0.96) | CA12CA1CA2CA7CA9 | |
| Ethylparaben SCHEMBL29374744 | 0.96 | CA12 (0.96) | CA12CA1CA2CA7CA9 | |
| Ethylparaben SCHEMBL23497074 | 0.96 | CA12 (0.96) | CA12CA1CA2CA7CA9 | |
| Ethylparaben SCHEMBL31347872 | 0.96 | CA12 (0.96) | CA12CA1CA2CA7CA9 | |
| Ethylparaben SCHEMBL476012 | 0.96 | CA12 (0.96) | CA12CA1CA2CA7CA9 | |
| Ethylparaben SCHEMBL31655760 | 0.96 | CA12 (0.96) | CA12CA1CA2CA7CA9 | |
| Ethylparaben SCHEMBL29358972 | 0.96 | CA12 (0.96) | CA12CA1CA2CA7CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113613650-B | Muscarinic acetylcholine receptor subtype 4 antagonists for treating anemia | 冷泉港实验室 | 2024-12-10 | — | — | CN | disclosed |
| CN-113613650-A | Muscarinic acetylcholine receptor subtype 4 antagonists for the treatment of anemia | 冷泉港实验室 | 2021-11-05 | — | — | CN | disclosed |