⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1189930 | 1.00 | — | — | |
| SCHEMBL25673513 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL1466672 | 0.97 | SLC1A3 (0.37) | — | |
| Hydrochloric Acid SCHEMBL836692 | 0.97 | SLC1A3 (0.37) | — | |
| Trifluoroacetic Acid SCHEMBL2496872 | 0.85 | DPP8 (0.38) | — | |
| SCHEMBL8207593 | 0.80 | SLC1A2 (0.42) | — | |
| SCHEMBL12709894 | 0.80 | DPP4 (0.39) | — | |
| SCHEMBL11342489 | 0.80 | SLC1A2 (0.42) | — | |
| SCHEMBL4103974 | 0.79 | — | — | |
| SCHEMBL15765659 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070161633-A1 | 4-Bromo-5-(2-chloro-benzoylamino)-1h-pyrazole-3-carboxylic acid (1-aminocarbonyl)eth-1-yl) amide derivatives and related compounds as bradykinin b1 receptor antagonists for the treatment of inflammatory diseases | ELAN PHARMACEUTICALS, INC. (US) | 2007-07-12 | — | — | US | claimed |
| US-9216173-B2 | 2-Pyridyl carboxamide-containing spleen tyrosine kinase (SYK) inhibitors | MERCK SHARP & DOHME CORP. (US) | 2015-12-22 | — | — | US | disclosed |
| US-20140243336-A1 | 2-Pyridyl Carboxamide-Containing Spleen Tyrosine Kinase (SYK) Inhibitors | MERCK SHARP & DOHME LLC | 2014-08-28 | — | — | US | disclosed |
| EP-0848053-B1 | Mixtures of esterified carboxy-containing interpolymers and lubricants containing them | LUBRIZOL CORP (US) | 2010-09-29 | — | — | EP | disclosed |
| EP-1200541-B1 | NITROGEN-CONTAINING ESTERIFIED CARBOXY-CONTAINING INTERPOLYMERS HAVING ENHANCED OXIDATIVE STABILITY AND LUBRICANTS CONTAINING THEM | LUBRIZOL CORP (US) | 2010-02-10 | — | — | EP | disclosed |
| US-20070161633-A1 | 4-Bromo-5-(2-chloro-benzoylamino)-1h-pyrazole-3-carboxylic acid (1-aminocarbonyl)eth-1-yl) amide derivatives and related compounds as bradykinin b1 receptor antagonists for the treatment of inflammatory diseases | ELAN PHARMACEUTICALS, INC. (US) | 2007-07-12 | — | — | US | disclosed |
| US-20050038099-A1 | Substituted pyrazole derivatives and related compounds as bradykinin B1 receptor antagonists | ELAN PHARMACEUTICALS, INC. | 2005-02-17 | — | — | US | disclosed |
| EP-0853115-B1 | Additive concentrates containing mixtures of organic diluents and esterified carboxy-containing interpolymers and lubricants containing them | LUBRIZOL CORP (US) | 2004-11-17 | — | — | EP | disclosed |
| US-6544935-B1 | Useful as viscosity improvers | THE LUBRIZOL CORPORATION | 2003-04-08 | — | — | US | disclosed |
| EP-1200541-A1 | NITROGEN-CONTAINING ESTERIFIED CARBOXY-CONTAINING INTERPOLYMERS HAVING ENHANCED OXIDATIVE STABILITY AND LUBRICANTS CONTAINING THEM | The Lubrizol Corporation (US) | 2002-05-02 | — | — | EP | disclosed |
| WO-2001004242-A1 | NITROGEN-CONTAINING ESTERIFIED CARBOXY-CONTAINING INTERPOLYMERS HAVING ENHANCED OXIDATIVE STABILITY AND LUBRICANTS CONTAINING THEM | THE LUBRIZOL CORPORATION (US) | 2001-01-18 | — | — | WO | disclosed |
| JP-2000319276-A | PRODUCTION OF CHIRAL IMIDAZOLINONE HERBICIDE | AMERICAN CYANAMID CO | 2000-11-21 | — | — | JP | disclosed |
| US-5880074-A | ADDITIVE CONCENTRATE COMPRISING DILUENT SELECTED FROM SYNTHETIC OIL OR NAPHTHENIC OILS, AN ESTER DERIVED FROM A CARBOXY-CONTAINING INTERPOLYMER HAVING REDUCED SPECIFIC VISCOSITY; GOOD LOW TEMPERATURE CHARACTERISTICS | LUBRIZOL CORPORATION THE | 1999-03-09 | — | — | US | disclosed |
| EP-0853115-A1 | Additive concentrates containing mixtures of organic diluents and esterified carboxy-containing interpolymers and lubricants containing them | The Lubrizol Corporation (US) | 1998-07-15 | — | — | EP | disclosed |
| EP-0848053-A1 | Mixtures of esterified carboxy-containing interpolymers and lubricants containing them | The Lubrizol Corporation (US) | 1998-06-17 | — | — | EP | disclosed |
| US-5707943-A | EXTREME TEMPERATURE ADDITIVES, POUR POINT DEPRESSANTS, AMIDATION, ESTERIFICATION, TRANSESTERIFICATION, TRANSAMIDATION OF ACRYLIC ACID OR ANHYDRIDE COPOLYMERS | THE LUBRIZOL CORPORATION (US) | 1998-01-13 | — | — | US | disclosed |
| US-5637557-A | EMULSIFYING MIXTURE OF A BRINE AND LIQUID OIL | THE LUBRIZOL CORPORATION (US) | 1997-06-10 | — | — | US | disclosed |
| US-5283235-A | Drilling and wqell completin fluids of a water in oil emulsion comprising a mixture of a brine, liquid hydrocarbon and a alpha-olefin or vinyl aromatic/acrylic acid or anhydride modified by a fatty alcohol | THE LUBRIZOL CORPORATION (US) | 1994-02-01 | — | — | US | disclosed |
| EP-0561608-A2 | Compositions containing esters of carboxy-containing interpolymers and methods of using the same | THE LUBRIZOL CORPORATION (US) | 1993-09-22 | — | — | EP | disclosed |
| EP-0561601-A2 | Compositions containing derivatives of succinic acylating agent or hydroxyaromatic compounds and methods of using the same | THE LUBRIZOL CORPORATION (US) | 1993-09-22 | — | — | EP | disclosed |