Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 8/20 | 0.44 |
| ▸ | TDO2 | P48775 | 6/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.41 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.40 |
| ▸ | NOS3 | P29474 | 1/20 | 0.40 |
| ▸ | NOS2 | P35228 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5799572 | 0.83 | IDO1 (0.49) | LMNAIDO1TDO2TAAR1HTR2A | |
| SCHEMBL36373 | 0.81 | LMNA (0.50) | LMNATAAR1HTR2ASLC7A5SLC6A4 | |
| SCHEMBL2792023 | 0.81 | LMNA (0.50) | LMNATAAR1HTR2ASLC7A5AOC3 | |
| Hydrochloric Acid SCHEMBL9340764 | 0.81 | IDO1 (0.51) | IDO1TDO2AOC3SLC6A4 | |
| SCHEMBL1520922 | 0.79 | TAAR1 (0.54) | IDO1TDO2TAAR1HTR2ANOS2 | |
| SCHEMBL1068693 | 0.79 | LMNA (0.48) | LMNATAAR1HTR2ASLC7A5AOC3 | |
| SCHEMBL8269660 | 0.79 | LMNA (0.48) | LMNATAAR1HTR2ASLC7A5AOC3 | |
| SCHEMBL11915432 | 0.79 | LMNA (0.48) | LMNATAAR1HTR2ASLC7A5AOC3 | |
| SCHEMBL1411711 | 0.77 | LMNA (0.52) | LMNASLC7A5AOC3NOS3NOS2 | |
| SCHEMBL12981312 | 0.77 | LMNA (0.46) | LMNATAAR1HTR2ASLC7A5AOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2227233-A2 | IDO INHIBITORS | Newlink Genetics (US) | 2010-09-15 | — | — | EP | claimed |
| WO-2009073620-A2 | IDO INHIBITORS | NEWLINK GENETICS (US) | 2009-06-11 | — | — | WO | claimed |
| WO-2019051198-A1 | PRODRUG INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE 1 (IDO1) | LANKENAU INSTITUTE FOR MEDICAL RESEARCH (US) | 2019-03-14 | — | — | WO | disclosed |
| CN-109370997-A | A kind of Phenylalanine aminomutase mutant | 江南大学 | 2019-02-22 | — | — | CN | disclosed |
| CN-109337891-A | A kind of Phenylalanine aminomutase mutant that thermal stability improves | 江南大学 | 2019-02-15 | — | — | CN | disclosed |
| CN-108004225-A | A kind of mutant of the Phenylalanine aminomutase in pantoea agglomerans source | 江南大学 | 2018-05-08 | — | — | CN | disclosed |
| CN-104644578-A | Sitagliptin phosphate composition tablet and preparation method thereof | TIANJIN HANKANG PHARMACEUTICAL BIOTECHNOLOGY CO LTD | 2015-05-27 | — | — | CN | disclosed |
| CN-104650087-A | Sitagliptin phosphate anhydrous compound | TIANJIN HANKANG PHARMACEUTICAL BIOTECHNOLOGY CO LTD | 2015-05-27 | — | — | CN | disclosed |
| CN-1760173-A | Method for synthesizing o-aminophenylpropyl alcohol | UNIV SHANGHAI (CN) | 2006-04-19 | — | — | CN | disclosed |