Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 4/20 | 0.41 |
| ▸ | HTR1A | P08908 | 3/20 | 0.41 |
| ▸ | HTR2A | P28223 | 3/20 | 0.41 |
| ▸ | HTR7 | P34969 | 3/20 | 0.41 |
| ▸ | DRD3 | P35462 | 3/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 3/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | TDO2 | P48775 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 6/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 6/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 6/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 6/20 | 0.38 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29292811 | 1.00 | GPR119 (0.42) | GPR119DRD4HTR1AHTR2AHTR7 | |
| SCHEMBL26251315 | 0.78 | GPR119 (0.44) | GPR119DRD4HTR1AHTR2AHTR7 | |
| SCHEMBL26251318 | 0.78 | GPR119 (0.44) | GPR119DRD4HTR1AHTR2AHTR7 | |
| SCHEMBL21154010 | 0.74 | CNR2 (0.35) | GPR119DRD4HTR1AHTR2AHTR7 | |
| SCHEMBL21154522 | 0.74 | CNR2 (0.35) | GPR119DRD4HTR1AHTR2AHTR7 | |
| SCHEMBL21999969 | 0.74 | CNR2 (0.35) | GPR119DRD4HTR1AHTR2AHTR7 | |
| SCHEMBL21154527 | 0.74 | CNR2 (0.35) | GPR119DRD4HTR1AHTR2AHTR7 | |
| SCHEMBL22000882 | 0.74 | CNR2 (0.35) | GPR119DRD4HTR1AHTR2AHTR7 | |
| SCHEMBL25391039 | 0.74 | GPR119 (0.41) | GPR119DRD4HTR1AHTR2AHTR7 | |
| SCHEMBL25391307 | 0.74 | GPR119 (0.41) | GPR119DRD4HTR1AHTR2AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3735411-B1 | 1,3,4,5-TETRAHYDRO-2H-PYRIDO[4,3-B]INDOLE DERIVATIVES FOR THE TREATMENT, ALLEVIATION OR PREVENTION OF DISORDERS ASSOCIATED WITH TAU AGGREGATES LIKE ALZHEIMER`S DISEASE | AC IMMUNE SA (CH) | 2024-07-10 | — | — | EP | disclosed |