Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 17/20 | 0.50 |
| ▸ | NR1H3 | Q13133 | 17/20 | 0.50 |
| ▸ | POLA1 | P09884 | 2/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21552202 | 0.90 | NR1H2 (0.61) | NR1H2NR1H3POLA1 | |
| SCHEMBL29295347 | 0.90 | NR1H2 (0.61) | NR1H2NR1H3POLA1 | |
| SCHEMBL29292359 | 0.87 | NR1H2 (0.43) | NR1H2NR1H3POLA1PDE4D | |
| SCHEMBL29292403 | 0.85 | NR1H2 (0.62) | NR1H2NR1H3 | |
| SCHEMBL21569998 | 0.85 | NR1H2 (0.45) | NR1H2NR1H3POLA1PDE4D | |
| SCHEMBL24591813 | 0.83 | NR1H2 (0.61) | NR1H2NR1H3POLA1 | |
| SCHEMBL29292394 | 0.83 | NR1H2 (0.36) | NR1H2NR1H3POLA1 | |
| SCHEMBL24591709 | 0.83 | NR1H2 (0.61) | NR1H2NR1H3POLA1 | |
| SCHEMBL27954308 | 0.83 | NR1H2 (0.61) | NR1H2NR1H3POLA1 | |
| SCHEMBL31097933 | 0.83 | NR1H2 (0.63) | NR1H2NR1H3POLA1PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3883926-B1 | BIS-OCTAHYDROPHENANTHRENE CARBOXAMIDE DERIVATIVES AND PROTEIN CONJUGATES THEREOF FOR USE AS LXR AGONISTS | REGENERON PHARMA (US) | 2024-07-10 | — | — | EP | disclosed |