⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bli-489 SCHEMBL2930081 | 1.00 | — | — | |
| Bli-489 SCHEMBL3549034 | 1.00 | — | — | |
| Bli-489 SCHEMBL5370434 | 0.99 | — | — | |
| Bli-489 SCHEMBL5370425 | 0.99 | — | — | |
| SCHEMBL13959069 | 0.93 | — | — | |
| Bli-489 SCHEMBL5370432 | 0.90 | — | — | |
| SCHEMBL3217524 | 0.85 | — | — | |
| SCHEMBL2929074 | 0.85 | — | — | |
| SCHEMBL2929072 | 0.85 | — | — | |
| SCHEMBL3553666 | 0.85 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007016134-A9 | BICYCLIC 6-ALKYLIDENE-PENEM B-LACTAMASE INHIBITORS AND β-LACTAM ANTIBIOTIC COMBINATION: A BROAD SPECTRUM ANTIBIOTIC | WYETH CORP (US) | 2009-03-12 | — | — | WO | claimed |
| EP-1988093-A1 | Bicyclic 6-alkylidene-penems as beta-lactamases inhibitors | Wyeth a Corporation of the State of Delaware (US) | 2008-11-05 | — | — | EP | claimed |
| EP-1906954-A1 | BICYCLIC 6-ALKYLIDENE-PENEM B-LACTAMASE INHIBITORS AND -LACTAM ANTIBIOTIC COMBINATION: A BROAD SPECTRUM ANTIBIOTIC | Wyeth Incoporated (US) | 2008-04-09 | — | — | EP | claimed |
| US-20070129344-A1 | Bicyclic 6-alkylidene-penem beta-lactamase inhibitors and beta-lactam antibiotic combination: a broad spectrum antibiotic | WYETH (US) | 2007-06-07 | — | — | US | claimed |
| WO-2007016134-A1 | BICYCLIC 6-ALKYLIDENE-PENEM B-LACTAMASE INHIBITORS AND β-LACTAM ANTIBIOTIC COMBINATION: A BROAD SPECTRUM ANTIBIOTIC | WYETH (US) | 2007-02-08 | — | — | WO | claimed |
| US-20060217361-A1 | Bicyclic 6-alkylidene-penems as beta-lactamase inhibitors | WYETH (US) | 2006-09-28 | — | — | US | claimed |
| EP-1499621-A1 | BICYCLIC 6-ALKYLIDENE-PENEMS AS BETA-LACTAMASES INHIBITORS | Wyeth (US) | 2005-01-26 | — | — | EP | claimed |
| US-20040077622-A1 | Bicyclic 5-alkylidene-penems as beta lactamases inhibitors | WYETH | 2004-04-22 | — | — | US | claimed |
| WO-2003093279-A1 | BICYCLIC 6-ALKYLIDENE-PENEMS AS ß-LACTAMASES INHIBITORS | WYETH (US) | 2003-11-13 | — | — | WO | claimed |
| EP-1499620-B1 | PROCESS FOR PREPARING 6-ALKYLIDENE PENEM DERIVATIVES | WYETH CORP (US) | 2010-01-27 | — | — | EP | disclosed |
| WO-2007016134-A9 | BICYCLIC 6-ALKYLIDENE-PENEM B-LACTAMASE INHIBITORS AND β-LACTAM ANTIBIOTIC COMBINATION: A BROAD SPECTRUM ANTIBIOTIC | WYETH CORP (US) | 2009-03-12 | — | — | WO | disclosed |
| US-20090018332-A1 | Processes For Preparing Bicyclic Oxazine Carboxaldehyde and Beta-Lactamase Inhibitors | WYETH (US) | 2009-01-15 | — | — | US | disclosed |
| EP-1988093-A1 | Bicyclic 6-alkylidene-penems as beta-lactamases inhibitors | Wyeth a Corporation of the State of Delaware (US) | 2008-11-05 | — | — | EP | disclosed |
| EP-1906954-A1 | BICYCLIC 6-ALKYLIDENE-PENEM B-LACTAMASE INHIBITORS AND -LACTAM ANTIBIOTIC COMBINATION: A BROAD SPECTRUM ANTIBIOTIC | Wyeth Incoporated (US) | 2008-04-09 | — | — | EP | disclosed |
| US-20070129344-A1 | Bicyclic 6-alkylidene-penem beta-lactamase inhibitors and beta-lactam antibiotic combination: a broad spectrum antibiotic | WYETH (US) | 2007-06-07 | — | — | US | disclosed |
| WO-2007016134-A1 | BICYCLIC 6-ALKYLIDENE-PENEM B-LACTAMASE INHIBITORS AND β-LACTAM ANTIBIOTIC COMBINATION: A BROAD SPECTRUM ANTIBIOTIC | WYETH (US) | 2007-02-08 | — | — | WO | disclosed |
| EP-1499621-A1 | BICYCLIC 6-ALKYLIDENE-PENEMS AS BETA-LACTAMASES INHIBITORS | Wyeth (US) | 2005-01-26 | — | — | EP | disclosed |
| US-20040077622-A1 | Bicyclic 5-alkylidene-penems as beta lactamases inhibitors | WYETH | 2004-04-22 | — | — | US | disclosed |
| WO-2003093279-A1 | BICYCLIC 6-ALKYLIDENE-PENEMS AS ß-LACTAMASES INHIBITORS | WYETH (US) | 2003-11-13 | — | — | WO | disclosed |