Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYCR1 | P32322 | 2/20 | 0.53 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.52 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 2/20 | 0.46 |
| ▸ | AGXT | P21549 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | PTGES | O14684 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21902238 | 0.89 | PYCR1 (0.51) | PYCR1TAAR1RIPK1HRH3SIGMAR1 | |
| SCHEMBL21902831 | 0.86 | TAAR1 (0.51) | PYCR1TAAR1RIPK1SIGMAR1BCHE | |
| SCHEMBL7766011 | 0.85 | HRH3 (0.56) | HRH3BCHECYP1A2CYP2D6CYP2C19 | |
| SCHEMBL9885275 | 0.83 | HRH3 (0.50) | HRH3BCHECYP1A2CYP2D6CYP2C19 | |
| SCHEMBL16399455 | 0.82 | PYCR1 (0.65) | PYCR1TAAR1RIPK1SIGMAR1IDO1 | |
| SCHEMBL8584537 | 0.82 | PYCR1 (0.42) | PYCR1TAAR1RIPK1SIGMAR1BCHE | |
| SCHEMBL8584533 | 0.82 | PYCR1 (0.42) | PYCR1TAAR1RIPK1SIGMAR1BCHE | |
| SCHEMBL27944031 | 0.81 | TAAR1 (0.53) | PYCR1TAAR1RIPK1IDO1AGXT | |
| SCHEMBL578605 | 0.79 | TAAR1 (0.66) | PYCR1TAAR1RIPK1SIGMAR1IDO1 | |
| SCHEMBL13181462 | 0.79 | HRH3 (0.50) | HRH3BCHECYP1A2CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160168118-A1 | N-(5-QUINOLIN-6-YL)PYRIDIN-3-YL) BENZSULFAMIDE DERIVATIVES, PREPARATION METHOD AND THERAPEUTIC USE THEREOF | SECOND MILITARY MEDICAL UNIVERSITY, PLA (CN) | 2016-06-16 | — | — | US | disclosed |
| US-20160168118-A1 | N-(5-QUINOLIN-6-YL)PYRIDIN-3-YL) BENZSULFAMIDE DERIVATIVES, PREPARATION METHOD AND THERAPEUTIC USE THEREOF | SECOND MILITARY MEDICAL UNIVERSITY, PLA (CN) | 2016-06-16 | — | — | US | disclosed |
| EP-2229377-A1 | 5-ALKYL/ALKENYL-3-CYANOPYRIDINES AS KINASE INHIBITORS | Wyeth LLC (US) | 2010-09-22 | — | — | EP | disclosed |
| WO-2009076602-A1 | 5-ALKYL/ALKENYL-3-CYANOPYRIDINES AS KINASE INHIBITORS | WYETH (US) | 2009-06-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160168118-A1 | N-(5-QUINOLIN-6-YL)PYRIDIN-3-YL) BENZSULFAMIDE DERIVATIVES, PREPARATION METHOD AND THERAPEUTIC USE THEREOF | GLS2, CYP3A5, HCCS | PYCR1 115/4885TAAR1 4395/4885RIPK1 4506/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.