Sugi Predict

Sugi Predict / Targets / PYCR1

PYCR1

Pyrroline-5-carboxylate reductase 1, mitochondrial · P32322 · PYCR1 on Sugi Atlas →

8,322 patent compounds predicted against PYCR1, 4,643 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
Pargyline Pargyline (SCHEMBL2045) 1.00 18/20
Pargyline Pargyline (SCHEMBL121111) 0.96 18/20
SCHEMBL711329 SCHEMBL711329 0.70 17/20
SCHEMBL610818 SCHEMBL610818 0.60 16/20
Pargyline Pargyline (SCHEMBL1240794) 0.65 14/20
SCHEMBL610837 SCHEMBL610837 0.72 13/20
SCHEMBL578205 SCHEMBL578205 0.43 11/20
SCHEMBL2059035 SCHEMBL2059035 0.50 9/20
SCHEMBL1241978 SCHEMBL1241978 0.62 8/20
SCHEMBL1241075 SCHEMBL1241075 0.60 8/20
SCHEMBL399795 SCHEMBL399795 0.55 8/20
SCHEMBL1639815 SCHEMBL1639815 0.52 8/20
SCHEMBL308737 SCHEMBL308737 0.61 7/20
SCHEMBL1241957 SCHEMBL1241957 0.59 7/20
SCHEMBL308505 SCHEMBL308505 0.61 6/20
SCHEMBL694707 SCHEMBL694707 0.57 6/20
SCHEMBL694708 SCHEMBL694708 0.57 6/20
SCHEMBL1239426 SCHEMBL1239426 0.57 6/20
SCHEMBL2479514 SCHEMBL2479514 0.57 6/20
SCHEMBL1240985 SCHEMBL1240985 0.51 6/20

Clinical trials — most relevant to PYCR1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Cardioprotective Empagliflozin for Cancer Patients Receiving Doxorubicin PHASE2/PHASE3UNKNOWN
Pioglitazone Therapy Targeting Fatigue in Breast Cancer PHASE2RECRUITING
The KHENEREXT Study PHASE2COMPLETED
Dynamics of Muscle Mitochondria in Type 2 Diabetes (DYNAMMO T2D) EARLY_PHASE1COMPLETED
Nicotinamide Riboside and Mitochondrial Biogenesis nanCOMPLETED
Mitochondrial Disease-associated ImmunoDeficiencies nanRECRUITING
Plasma Cytochrome c as Biomarker of Traumatic Injury and Predictor of Outcome nanCOMPLETED
Diabetic Cardiomyopathy and Heart Failure nanWITHDRAWN
A Study Into the Underlying Biochemical Pathways Involved in Parkinson's Disease, Such as Mitochondrial (Cellular Powerhouse) Dysfunction nanCOMPLETED
Polycystic Ovary Syndrome, Mitochondrial Dysfunction, Obesity, Insulin Resistance Infertility (POMODORI) Cohort nanRECRUITING
Relation of White Blood Cell Function to Diabetes nanCOMPLETED
Drug Repurposing for Mitochondrial Disorders Using iPSCs Derived Neural Cells nanRECRUITING
Mitoferrin-1 Expression in Erythropoietic Protoporphyria (Porphyria Rare Disease Clinical Research Consortium (RDCRC)) nanCOMPLETED
Tissue Sample Study for Mitochondrial Disorders nanENROLLING_BY_INVITATION
Mitochondrial Dysfunction in Diabetes nanCOMPLETED
Natural History Study of FDXR Mutation-related Mitochondriopathy nanCOMPLETED
Effect of Branched Chain Amino Acids on Muscle nanCOMPLETED
Measuring Protein Turnover in Humans Across the Lifespan by Metabolic Labeling With Deuterium Oxide nanRECRUITING
Diagnostic Odyssey Survey 2 nanCOMPLETED
Effect of Ketone Esters in Parkinson's Disease nanCOMPLETED
Mitochondrial Assessment in Critical Ill Patients in Intensive Care nanNOT_YET_RECRUITING
Mitigating Mitochondrial RNA Release During Aging to Control Inflammation and Senescence nanNOT_YET_RECRUITING
Dynamics of Muscle Mitochondria in Type 2 Diabetes Exercise nanCOMPLETED
Effect of Diaphragm Stimulation During Surgery nanCOMPLETED
Relationship Between Mitochondrial Dysfunction and Fatique in Cancer Patients Following External Beam Radiation Therapy nanCOMPLETED
Nicotinamide Levels in Serum, Aqueous Humor, and Tear Film in Glaucoma and Correlations With Mitochondrial Damage-Associated Molecular Patterns (mtDAMPs) and Senescence-Associated Secretory Phenotype (SASP) nanNOT_YET_RECRUITING
Effect of Subtle Energy Transmission and Tao Calligraphy Mindfulness Practice on Mitochondrial DNA in Peripheral Blood Leukocytes nanNOT_YET_RECRUITING
Mitochondrial Function of Immune Cells in Sepsis nanCOMPLETED
Mitochondrial Dysfunction Contributes to Sepsis Induced Cardiac Dysfunction nanWITHDRAWN
Cardiac Mitochondrial Function in Explanted Human Hearts nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a PYCR1 binder may also engage these)

ProteinNameSimilarity
Q5R9X6 — 1.000 Q5R9X6 →
Q17QJ7 — 1.000 Q17QJ7 →
Q4R6W7 — 1.000 Q4R6W7 →
Q6AY23 — 1.000 Q6AY23 →
Q5RAQ3 — 0.996 Q5RAQ3 →
Q58DT4 — 0.996 Q58DT4 →
Q922W5 — 0.995 Q922W5 →
Q96C36 — 0.995 Q96C36 →
Q922Q4 — 0.994 Q922Q4 →
Q5SPD7 — 0.988 Q5SPD7 →
A0A8B0M9T7 — 0.986 A0A8B0M9T7 →
A7MX60 — 0.983 A7MX60 →
Q4QHG4 — 0.983 Q4QHG4 →
Q9KNT0 — 0.982 Q9KNT0 →
Q87KZ2 — 0.982 Q87KZ2 →
A5F502 — 0.981 A5F502 →
C3LRW2 — 0.981 C3LRW2 →
Q55E34 — 0.981 Q55E34 →
Q12HV8 — 0.981 Q12HV8 →
Q8DCW4 — 0.981 Q8DCW4 →
Q5PQJ6 — 0.980 Q5PQJ6 →
B0B8U0 — 0.980 B0B8U0 →
P90551 — 0.980 P90551 →
Q7MY54 — 0.980 Q7MY54 →
Q6LVK9 — 0.980 Q6LVK9 →
A8HAD7 — 0.979 A8HAD7 →
B2VL53 — 0.979 B2VL53 →
B6J4L3 — 0.979 B6J4L3 →
A4SDK2 — 0.979 A4SDK2 →
Q949Q0 — 0.978 Q949Q0 →