Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2351395 | 1.00 | TSHR (0.44) | TSHRTHRBEPHX2 | |
| Ammonia Solution, Strong SCHEMBL20492547 | 0.97 | TSHR (0.42) | TSHRTHRBEPHX2 | |
| SCHEMBL16411503 | 0.97 | — | — | |
| SCHEMBL15059086 | 0.97 | TSHR (0.39) | TSHRTHRB | |
| Ammonia Solution, Strong SCHEMBL20492546 | 0.94 | TSHR (0.37) | TSHRTHRB | |
| SCHEMBL1155482 | 0.90 | TSHR (0.40) | TSHRTHRB | |
| SCHEMBL9636003 | 0.90 | TSHR (0.40) | TSHRTHRB | |
| SCHEMBL648728 | 0.88 | — | — | |
| SCHEMBL648729 | 0.88 | — | — | |
| SCHEMBL4462199 | 0.87 | TSHR (0.38) | TSHRTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240228506-A1 | RIPK1 INHIBITORS AND METHODS OF USE | MERCK SHARP & DOHME LLC (US) | 2024-07-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240228506-A1 | RIPK1 INHIBITORS AND METHODS OF USE | RIPK1, RIPK2, RIPK3 | TSHR 4236/4885THRB 3321/4885EPHX2 3686/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.