Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 8/20 | 0.56 |
| ▸ | WIZ | O95785 | 5/20 | 0.54 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.53 |
| ▸ | IKZF2 | Q9UKS7 | 5/20 | 0.53 |
| ▸ | TNF | P01375 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29311129 | 0.90 | CRBN (0.58) | CRBNWIZIKZF2TNF | |
| SCHEMBL25087643 | 0.90 | TNF (0.62) | CRBNWIZIKZF2TNF | |
| SCHEMBL24079649 | 0.89 | WIZ (0.63) | CRBNWIZIKZF2TNF | |
| SCHEMBL29310988 | 0.89 | CRBN (0.57) | CRBNWIZIKZF2TNF | |
| SCHEMBL22536267 | 0.89 | CRBN (0.58) | CRBNWIZIKZF2TNF | |
| SCHEMBL25035421 | 0.89 | CRBN (0.61) | CRBNWIZIKZF2TNF | |
| SCHEMBL24079533 | 0.88 | WIZ (0.56) | CRBNWIZIKZF2TNF | |
| SCHEMBL24079953 | 0.88 | TNF (0.54) | CRBNWIZIKZF2TNF | |
| SCHEMBL25087399 | 0.88 | IKZF2 (0.60) | CRBNWIZIKZF3IKZF2TNF | |
| SCHEMBL29311025 | 0.88 | CRBN (0.60) | CRBNWIZIKZF2TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024148088-A1 | SPIROCYCLOALKYL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THAT MODULATE IKZF2 | Plexium, Inc. (US) | 2024-07-11 | — | — | WO | disclosed |