Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 2/20 | 0.74 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | TACR1 | P25103 | 4/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | SMO | Q99835 | 2/20 | 0.34 |
| ▸ | MMP2 | P08253 | 3/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2931273 | 1.00 | IGF1R (0.74) | IGF1RHSD11B1TACR1HDAC6KDM4E | |
| Trifluoroacetic Acid SCHEMBL3739554 | 0.96 | IGF1R (0.69) | IGF1RHSD11B1TACR1HDAC6PTGDR2 | |
| SCHEMBL2934906 | 0.93 | IGF1R (0.70) | IGF1RHSD11B1TACR1HDAC6ALDH1A1 | |
| SCHEMBL2934912 | 0.93 | IGF1R (0.70) | IGF1RHSD11B1TACR1HDAC6ALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL3724562 | 0.91 | IGF1R (0.65) | IGF1RHSD11B1TACR1HDAC6LMNA | |
| Trifluoroacetic Acid SCHEMBL2935701 | 0.91 | IGF1R (0.65) | IGF1RHSD11B1TACR1HDAC6LMNA | |
| SCHEMBL2940864 | 0.90 | IGF1R (0.72) | IGF1RHSD11B1HDAC6KDM4EALDH1A1 | |
| SCHEMBL2940866 | 0.90 | IGF1R (0.72) | IGF1RHSD11B1HDAC6KDM4EALDH1A1 | |
| SCHEMBL3724561 | 0.88 | IGF1R (0.63) | IGF1RHSD11B1TACR1HDAC6LMNA | |
| SCHEMBL2937103 | 0.87 | IGF1R (0.69) | IGF1RHSD11B1KDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-B1 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA SA (FR) | 2010-09-22 | — | — | EP | disclosed |