Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 2/20 | 0.65 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.34 |
| ▸ | TACR1 | P25103 | 3/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CASP6 | P55212 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | XIAP | P98170 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.32 |
| ▸ | MMP13 | P45452 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL3724562 | 1.00 | IGF1R (0.65) | IGF1RMMP2PTGDR2HDAC6TACR1 | |
| SCHEMBL2934912 | 0.96 | IGF1R (0.70) | IGF1RMMP2PTGDR2HDAC6TACR1 | |
| SCHEMBL2934906 | 0.96 | IGF1R (0.70) | IGF1RMMP2PTGDR2HDAC6TACR1 | |
| Trifluoroacetic Acid SCHEMBL3739554 | 0.95 | IGF1R (0.69) | IGF1RPTGDR2HDAC6TACR1HSD11B1 | |
| SCHEMBL2931273 | 0.91 | IGF1R (0.74) | IGF1RMMP2PTGDR2HDAC6TACR1 | |
| SCHEMBL2931269 | 0.91 | IGF1R (0.74) | IGF1RMMP2PTGDR2HDAC6TACR1 | |
| SCHEMBL3724561 | 0.89 | IGF1R (0.63) | IGF1RPTGDR2HDAC6TACR1HSD11B1 | |
| Trifluoroacetic Acid SCHEMBL3726914 | 0.88 | IGF1R (0.66) | IGF1RPTGDR2HDAC6TACR1HSD11B1 | |
| Trifluoroacetic Acid SCHEMBL3726949 | 0.87 | IGF1R (0.47) | IGF1RHDAC6GAA | |
| Trifluoroacetic Acid SCHEMBL3730823 | 0.86 | IGF1R (0.63) | IGF1RPTGDR2TACR1HSD11B1XIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-B1 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA SA (FR) | 2010-09-22 | — | — | EP | claimed |