Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | CRHR1 | P34998 | 7/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2497805 | 0.92 | HPGD (0.38) | HPGDPOLBKDM4EMAPTCRHR1 | |
| SCHEMBL2498882 | 0.87 | POLB (0.39) | HPGDPOLBKDM4EMAPTCRHR1 | |
| SCHEMBL545543 | 0.86 | HPGD (0.40) | HPGDPOLBKDM4EMAPTCRHR1 | |
| SCHEMBL2930712 | 0.85 | CRHR1 (0.39) | HPGDPOLBKDM4EMAPTCRHR1 | |
| SCHEMBL544959 | 0.84 | CRHR1 (0.40) | HPGDPOLBKDM4EMAPTCRHR1 | |
| SCHEMBL2497127 | 0.82 | CRHR1 (0.38) | HPGDPOLBKDM4EMAPTCRHR1 | |
| SCHEMBL12409295 | 0.82 | CRHR1 (0.40) | HPGDPOLBKDM4EMAPTCRHR1 | |
| SCHEMBL2499635 | 0.81 | HPGD (0.34) | HPGDPOLBKDM4EMAPTCRHR1 | |
| SCHEMBL2178265 | 0.81 | CRHR1 (0.39) | HPGDPOLBKDM4EMAPTCRHR1 | |
| SCHEMBL2495293 | 0.81 | HPGD (0.39) | HPGDPOLBKDM4EMAPTCRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094709-B1 | THIAZOLE PYRAZOLOPYRIMIDINES AS CRF1 RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2010-09-15 | — | — | EP | disclosed |