Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K7 | O43318 | 6/20 | 0.64 |
| ▸ | IRAK1 | P51617 | 6/20 | 0.64 |
| ▸ | IRAK4 | Q9NWZ3 | 6/20 | 0.64 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.48 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MET | P08581 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29313501 | 0.93 | MAP3K7 (0.55) | MAP3K7IRAK1IRAK4ADORA2AMAPT | |
| SCHEMBL29313493 | 0.91 | MAP3K7 (0.77) | MAP3K7IRAK1IRAK4ALKMAPT | |
| SCHEMBL21025881 | 0.89 | IRAK4 (0.82) | MAP3K7IRAK1IRAK4ADORA2AALK | |
| SCHEMBL29313976 | 0.85 | MAP3K7 (0.85) | MAP3K7IRAK1IRAK4ALKMET | |
| SCHEMBL29313489 | 0.83 | IRAK4 (0.66) | MAP3K7IRAK1IRAK4ALKMAPT | |
| SCHEMBL21025639 | 0.82 | IRAK4 (0.71) | MAP3K7IRAK1IRAK4EGFR | |
| SCHEMBL29313511 | 0.81 | IRAK4 (0.68) | MAP3K7IRAK1IRAK4ALKMET | |
| SCHEMBL29313971 | 0.80 | MAP3K7 (0.86) | MAP3K7IRAK1IRAK4EGFR | |
| SCHEMBL13594638 | 0.79 | MAP3K7 (0.68) | MAP3K7IRAK1IRAK4ALKSMN1; SMN2 | |
| SCHEMBL1923717 | 0.79 | MAP3K7 (0.88) | MAP3K7IRAK1IRAK4ALKKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12036209-B2 | Compounds and methods for the targeted degradation of Interleukin-1 receptor-associated kinase 4 polypeptides | ARVINAS OPERATIONS, INC. (US) | 2024-07-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12036209-B2 | Compounds and methods for the targeted degradation of Interleukin-1 receptor-associated kinase 4 polypeptides | IRAK1, IRAK4, IRAK2 | MAP3K7 533/4885IRAK1 1/4885IRAK4 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.