Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 9/20 | 0.39 |
| ▸ | DHFR | P00374 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.35 |
| ▸ | KLK1 | P06870 | 1/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.35 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.35 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | EP300 | Q09472 | 1/20 | 0.35 |
| ▸ | MEF2D | Q14814 | 1/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29317471 | 0.90 | NPC1 (0.43) | NPC1KDRDHFRHDAC6MET | |
| SCHEMBL29314413 | 0.89 | NPC1 (0.38) | NPC1KDRDHFRHDAC6MET | |
| SCHEMBL21167629 | 0.87 | NPC1 (0.44) | NPC1KDRDHFRHDAC6MET | |
| SCHEMBL21167454 | 0.86 | NPC1 (0.44) | NPC1KDRDHFRHDAC6MET | |
| SCHEMBL29318034 | 0.85 | NPC1 (0.40) | NPC1KDRDHFRHDAC6MET | |
| SCHEMBL21167657 | 0.85 | NPC1 (0.42) | NPC1KDRDHFRHDAC6MET | |
| SCHEMBL21167366 | 0.85 | NPC1 (0.43) | NPC1KDRDHFRHDAC6MET | |
| SCHEMBL21167728 | 0.84 | NPC1 (0.43) | NPC1KDRDHFRHDAC6MET | |
| SCHEMBL21167575 | 0.83 | NPC1 (0.41) | NPC1KDRDHFRHDAC6MET | |
| SCHEMBL21167592 | 0.83 | NPC1 (0.42) | NPC1KDRDHFRHDAC6MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3893872-B1 | ORGANOPHOSPHORUS-SUBSTITUTED COMPOUNDS AS C-MET INHIBITORS AND THERAPEUTIC USES THEREOF | BETA PHARMA INC (US) | 2024-07-17 | — | — | EP | disclosed |