Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLQ | O75417 | 2/20 | 0.39 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.32 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.32 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TACR1 | P25103 | 3/20 | 0.31 |
| ▸ | RXRA | P19793 | 1/20 | 0.31 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.31 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.31 |
| ▸ | LIPE | Q05469 | 3/20 | 0.30 |
| ▸ | CMA1 | P23946 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30847572 | 1.00 | POLQ (0.39) | POLQCACNA1GCACNA1BCACNA1CMEN1 | |
| SCHEMBL31009150 | 0.94 | POLQ (0.41) | POLQMEN1KMT2ATACR1 | |
| SCHEMBL31009196 | 0.86 | POLQ (0.35) | POLQTACR1 | |
| SCHEMBL29315670 | 0.86 | POLQ (0.35) | POLQTACR1 | |
| SCHEMBL29313609 | 0.82 | POLQ (0.40) | POLQLIPECMA1 | |
| SCHEMBL29313612 | 0.80 | POLQ (0.38) | POLQLIPECMA1 | |
| SCHEMBL29313708 | 0.80 | POLQ (0.38) | POLQTACR1LIPE | |
| SCHEMBL31009168 | 0.80 | POLQ (0.34) | POLQ | |
| SCHEMBL29313703 | 0.80 | TACR1 (0.39) | POLQTACR1 | |
| SCHEMBL29313751 | 0.80 | POLQ (0.39) | POLQTACR1CMA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024147972-A2 | DNA POLYMERASE THETA INHIBITORS CONTAINING NON-SATURATED 5-MEMBERED HETEROCYCLIC RINGS AND USE THEREOF | THOMAS JEFFERSON UNIVERSITY (US) | 2024-07-11 | — | — | WO | disclosed |