SCHEMBL29315035

SCHEMBL29315035

BC(O)(O)N(C(=O)Oc1c(C#CSI)cc(C(F)(F)F)cc1C(F)(F)F)c1ccc(F)cc1

nearest known ligand 0.33

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
POLQ O75417 5/20 0.33
AR P10275 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29315030 0.96 POLQ (0.34) POLQAR
SCHEMBL29314841 0.93 POLQ (0.34) POLQ
SCHEMBL29314395 0.85 POLQ (0.43) POLQ
SCHEMBL29316015 0.82
SCHEMBL29315472 0.78 POLQ (0.30) POLQ
SCHEMBL29316401 0.76 POLQ (0.30) POLQ
SCHEMBL29315012 0.73 POLQ (0.41) POLQ
SCHEMBL29314831 0.72 POLQ (0.42) POLQAR
SCHEMBL31009186 0.71 POLQ (0.44) POLQ
SCHEMBL29314374 0.71 POLQ (0.44) POLQ

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024147972-A2 DNA POLYMERASE THETA INHIBITORS CONTAINING NON-SATURATED 5-MEMBERED HETEROCYCLIC RINGS AND USE THEREOF THOMAS JEFFERSON UNIVERSITY (US) 2024-07-11 WO disclosed