Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLQ | O75417 | 5/20 | 0.42 |
| ▸ | TACR1 | P25103 | 3/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.33 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29316532 | 0.89 | POLQ (0.32) | POLQLMNACES2TSHR | |
| SCHEMBL29315012 | 0.89 | POLQ (0.41) | POLQTACR1SLC6A4ALDH1A1LMNA | |
| SCHEMBL29314384 | 0.85 | POLQ (0.52) | POLQTACR1ALDH1A1LMNAKDM4E | |
| SCHEMBL29314388 | 0.76 | POLQ (0.50) | POLQALDH1A1LMNAGAARAB9A | |
| SCHEMBL30847596 | 0.74 | POLQ (0.50) | POLQLMNAGAARAB9ATSHR | |
| SCHEMBL30847733 | 0.74 | TACR1 (0.44) | POLQTACR1SLC6A4 | |
| SCHEMBL29315030 | 0.73 | POLQ (0.34) | POLQAR | |
| SCHEMBL30847641 | 0.72 | POLQ (0.43) | POLQTACR1ALDH1A1LMNAKDM4E | |
| SCHEMBL29315955 | 0.72 | POLQ (0.36) | POLQ | |
| SCHEMBL29314375 | 0.71 | POLQ (0.47) | POLQLMNARAB9AAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024147972-A2 | DNA POLYMERASE THETA INHIBITORS CONTAINING NON-SATURATED 5-MEMBERED HETEROCYCLIC RINGS AND USE THEREOF | THOMAS JEFFERSON UNIVERSITY (US) | 2024-07-11 | — | — | WO | disclosed |