SCHEMBL29316050

SCHEMBL29316050

CP(C)(=O)c1ccc(-c2cnc3nnn(Cc4ccc5ncccc5c4)c3n2)nc1

nearest known ligand 0.63

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
MET P08581 20/20 0.63
CYP2C9 P11712 1/20 0.56
PDE3B Q13370 1/20 0.56
PDE3A Q14432 1/20 0.56
PDE10A Q9Y233 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30948868 0.90 MET (0.75) METCYP2C9PDE3BPDE3APDE10A
SCHEMBL22109390 0.90 MET (0.75) METCYP2C9PDE3BPDE3APDE10A
SCHEMBL22109339 0.88 MET (0.61) METCYP2C9PDE3BPDE3APDE10A
SCHEMBL22109395 0.86 MET (0.67) METCYP2C9PDE3BPDE3APDE10A
SCHEMBL30948878 0.86 MET (0.67) METCYP2C9PDE3BPDE3APDE10A
SCHEMBL22109406 0.86 MET (0.64) METCYP2C9PDE3BPDE3APDE10A
SCHEMBL30948873 0.86 MET (0.64) METCYP2C9PDE3BPDE3APDE10A
SCHEMBL22109172 0.84 MET (0.64) MET
SCHEMBL29314630 0.84 MET (0.71) METCYP2C9PDE3BPDE3APDE10A
SCHEMBL30948871 0.84 MET (0.72) MET

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3893872-B1 ORGANOPHOSPHORUS-SUBSTITUTED COMPOUNDS AS C-MET INHIBITORS AND THERAPEUTIC USES THEREOF BETA PHARMA INC (US) 2024-07-17 EP disclosed