Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28711958 | 0.81 | ALDH1A1 (0.54) | KDM4EALDH1A1GAAHPGDSMN1; SMN2 | |
| SCHEMBL8456705 | 0.81 | CYP1A2 (0.43) | KDM4EALDH1A1MAPTLMNAGAA | |
| SCHEMBL6848695 | 0.79 | KDM4E (0.54) | KDM4EALDH1A1MAPTJAK2LMNA | |
| SCHEMBL11342206 | 0.78 | CYP1A2 (0.49) | ALDH1A1MAPTLMNAL3MBTL1HPGD | |
| SCHEMBL28867053 | 0.77 | HTT (0.50) | KDM4EALDH1A1MAPTHTTSMN1; SMN2 | |
| SCHEMBL10430488 | 0.77 | MEN1 (0.50) | ALDH1A1MAPTLMNAL3MBTL1HPGD | |
| SCHEMBL5929953 | 0.77 | MEN1 (0.50) | ALDH1A1MAPTLMNAL3MBTL1HPGD | |
| SCHEMBL3469016 | 0.77 | MEN1 (0.50) | ALDH1A1MAPTLMNAL3MBTL1HPGD | |
| SCHEMBL4461566 | 0.77 | MEN1 (0.50) | ALDH1A1MAPTLMNAL3MBTL1HPGD | |
| SCHEMBL31546843 | 0.76 | ALDH1A1 (0.50) | KDM4EALDH1A1MAPTGAAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229377-A1 | 5-ALKYL/ALKENYL-3-CYANOPYRIDINES AS KINASE INHIBITORS | Wyeth LLC (US) | 2010-09-22 | — | — | EP | disclosed |
| WO-2009076602-A1 | 5-ALKYL/ALKENYL-3-CYANOPYRIDINES AS KINASE INHIBITORS | WYETH (US) | 2009-06-18 | — | — | WO | disclosed |