Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 20/20 | 0.57 |
| ▸ | HTR1A | P08908 | 2/20 | 0.52 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.52 |
| ▸ | HTR2A | P28223 | 2/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.52 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.52 |
| ▸ | HTR2B | P41595 | 2/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2931711 | 1.00 | REN (0.57) | RENHTR1AADRA1DHTR2AADRA1A | |
| SCHEMBL13404589 | 1.00 | REN (0.57) | RENHTR1AADRA1DHTR2AADRA1A | |
| SCHEMBL2934646 | 0.92 | REN (0.57) | RENHTR1AADRA1DHTR2AADRA1A | |
| SCHEMBL8262511 | 0.92 | REN (0.60) | RENHTR1AADRA1DHTR2AADRA1A | |
| SCHEMBL2937059 | 0.90 | REN (0.54) | RENHTR1AADRA1DHTR2AADRA1A | |
| SCHEMBL13438544 | 0.89 | REN (0.57) | RENHTR1AADRA1DHTR2AADRA1A | |
| SCHEMBL2932548 | 0.89 | REN (0.57) | RENHTR1AADRA1DHTR2AADRA1A | |
| SCHEMBL8264534 | 0.88 | REN (0.60) | RENHTR1AADRA1DHTR2AADRA1A | |
| SCHEMBL3611260 | 0.88 | REN (0.60) | RENHTR1AADRA1DHTR2AADRA1A | |
| SCHEMBL2932226 | 0.88 | REN (0.60) | RENHTR1AADRA1DHTR2AADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8809348-B2 | 6-arylmethyl substituted pyrazolo[3,4-d]pyrimidines | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-08-19 | — | — | US | disclosed |
| EP-1836163-B1 | PYRROLIDINE DERIVATIVES FOR THE TREATMENT OF A DISEASE DEPENDING ON THE ACTIVITY OF RENIN | NOVARTIS AG (CH) | 2010-09-22 | — | — | EP | disclosed |
| US-20100087427-A1 | PYRROLIDINE DERIVATIVES FOR THE TREATMENT OF A DISEASE DEPENDING ON THE ACTIVITY OF RENIN | BREITENSTEIN WERNER | 2010-04-08 | — | — | US | disclosed |
| US-20100035900-A1 | 6-Arylmethyl-substituted pyrazolopyrimidines | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-02-11 | — | — | US | disclosed |
| US-7615558-B2 | 6-arylmethylprazolo[3,4-d]pyrimidines | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-11-10 | — | — | US | disclosed |
| EP-1836163-A2 | PYRROLIDINE DERIVATIVES FOR THE TREATMENT OF A DISEASE DEPENDING ON THE ACTIVITY OF RENIN | Novartis AG (CH) | 2007-09-26 | — | — | EP | disclosed |
| US-20070161662-A1 | 6-Arylmethyl-substituted pyrazolopyrimidines | BAYER HEALTHCARE AG (DE) | 2007-07-12 | — | — | US | disclosed |
| WO-2006066896-A2 | PYRROLIDINE DERIVATIVES FOR THE TREATMENT OF A DISEASE DEPENDING ON THE ACTIVITY OF RENIN | NOVARTIS AG (CH) | 2006-06-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100087427-A1 | PYRROLIDINE DERIVATIVES FOR THE TREATMENT OF A DISEASE DEPENDING ON THE ACTIVITY OF RENIN | REN, ACE, PEPD | REN 1/4885HTR1A 2770/4885ADRA1D 114/4885 |
| US-20100035900-A1 | 6-Arylmethyl-substituted pyrazolopyrimidines | P2RX6, P2RY6, GRM6 | REN 2063/4885HTR1A 588/4885ADRA1D 373/4885 |
| US-20070161662-A1 | 6-Arylmethyl-substituted pyrazolopyrimidines | P2RX6, P2RY6, GRM6 | REN 2063/4885HTR1A 588/4885ADRA1D 373/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.