Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | POLQ | O75417 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 2/20 | 0.33 |
| ▸ | NMT1 | P30419 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | UBE2N | P61088 | 1/20 | 0.32 |
| ▸ | FNTA | P49354 | 1/20 | 0.31 |
| ▸ | FNTB | P49356 | 1/20 | 0.31 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21252647 | 0.72 | — | — | |
| SCHEMBL3347212 | 0.71 | TDP1 (0.40) | TDP1HSP90AA1ATMNMT1IDO1 | |
| SCHEMBL12590718 | 0.69 | TDP1 (0.38) | TLR7TDP1HSP90AA1ATMNMT1 | |
| SCHEMBL18430927 | 0.69 | TDP1 (0.38) | TDP1HSP90AA1ATMNMT1IDO1 | |
| SCHEMBL12820173 | 0.68 | TDP1 (0.44) | TDP1POLQHSP90AA1ATMCYP2D6 | |
| SCHEMBL378803 | 0.67 | — | — | |
| SCHEMBL1570065 | 0.67 | — | — | |
| SCHEMBL24958879 | 0.63 | TDP1 (0.35) | TDP1HSP90AA1NMT1 | |
| SCHEMBL22535086 | 0.63 | NMT1 (0.35) | TDP1POLQHSP90AA1ATMNMT1 | |
| SCHEMBL13743863 | 0.63 | GRM5 (0.45) | TDP1HSP90AA1ATMNMT1CHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024147972-A2 | DNA POLYMERASE THETA INHIBITORS CONTAINING NON-SATURATED 5-MEMBERED HETEROCYCLIC RINGS AND USE THEREOF | THOMAS JEFFERSON UNIVERSITY (US) | 2024-07-11 | — | — | WO | disclosed |