Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12605242 | 1.00 | SMN1; SMN2 (0.46) | SMN1; SMN2SIGMAR1MEN1KMT2AKDM4E | |
| SCHEMBL20328696 | 0.93 | SMN1; SMN2 (0.44) | SMN1; SMN2SIGMAR1MEN1KMT2ACXCR4 | |
| SCHEMBL20328701 | 0.90 | SMN1; SMN2 (0.44) | SMN1; SMN2SIGMAR1MEN1KMT2AKDM4E | |
| SCHEMBL8042099 | 0.89 | SIGMAR1 (0.53) | SMN1; SMN2SIGMAR1MEN1KMT2ACXCR4 | |
| SCHEMBL20328703 | 0.86 | SMN1; SMN2 (0.44) | SMN1; SMN2SIGMAR1MEN1KMT2AALDH1A1 | |
| SCHEMBL2621583 | 0.85 | SMN1; SMN2 (0.49) | SMN1; SMN2SIGMAR1MEN1KMT2AALDH1A1 | |
| SCHEMBL20322411 | 0.85 | KDM4E (0.39) | SMN1; SMN2SIGMAR1MEN1KMT2AKDM4E | |
| SCHEMBL20333243 | 0.85 | MEN1 (0.41) | SMN1; SMN2SIGMAR1MEN1KMT2AKDM4E | |
| SCHEMBL20328691 | 0.83 | KDM4E (0.46) | SMN1; SMN2MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL23987984 | 0.82 | CXCR4 (0.52) | SMN1; SMN2SIGMAR1MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4397661-A1 | COMPOUND FOR DEGRADATION OF BCL-2 FAMILY PROTEINS AND MEDICAL APPLICATION THEREOF | Xizang Haisco Pharmaceutical Co., Ltd. (CN) | 2024-07-10 | — | — | EP | disclosed |