Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 14/20 | 0.38 |
| ▸ | CSNK1D | P48730 | 4/20 | 0.38 |
| ▸ | CSNK1E | P49674 | 4/20 | 0.38 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.36 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2929429 | 0.89 | MAPK14 (0.45) | MAPK14CSNK1DCSNK1ECSNK1A1MAPK13 | |
| SCHEMBL2926478 | 0.87 | MAPK14 (0.43) | MAPK14CSNK1DCSNK1ECSNK1A1MAPK13 | |
| SCHEMBL2930642 | 0.86 | MAPK14 (0.42) | MAPK14CSNK1DCSNK1ECSNK1A1MAPK13 | |
| SCHEMBL2929818 | 0.86 | MAPK14 (0.43) | MAPK14CSNK1DCSNK1ECSNK1A1MAPK13 | |
| SCHEMBL2930511 | 0.86 | MAPK14 (0.42) | MAPK14CSNK1DCSNK1ECSNK1A1MAPK13 | |
| SCHEMBL2931774 | 0.83 | MAPK14 (0.44) | MAPK14CSNK1DCSNK1ECSNK1A1MAPK13 | |
| SCHEMBL2929740 | 0.83 | MAPK14 (0.41) | MAPK14CSNK1DCSNK1ECSNK1A1MAPK13 | |
| SCHEMBL2926830 | 0.83 | MAPK14 (0.45) | RIPK3MAPK14CSNK1DCSNK1ECSNK1A1 | |
| SCHEMBL1384858 | 0.83 | MAPK14 (0.43) | MAPK14CSNK1DCSNK1ECSNK1A1MAPK13 | |
| SCHEMBL1387096 | 0.82 | ALOX5 (0.43) | MAPK14CSNK1DCSNK1ECSNK1A1MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8536194-B2 | Pyrazolopyridine derivates | PALAU PHARMA, S.A. (ES) | 2013-09-17 | — | — | US | claimed |
| EP-1611131-B1 | PYRAZOLOPYRIDINE DERIVATES | PALAU PHARMA SA (ES) | 2010-09-15 | — | — | EP | claimed |
| US-20090005377-A1 | Pyrazolopyridine Derivates | PALAU PHARMA, S.A. (ES) | 2009-01-01 | — | — | US | claimed |
| US-7468376-B2 | Pyrazolopyridine derivates | PALAU PHARMA, S.A. (ES) | 2008-12-23 | — | — | US | claimed |
| US-20060167040-A1 | Pyrazolopyridine derivates | J. URIACH Y COMPANIA S.A. (ES) | 2006-07-27 | — | — | US | claimed |
| EP-1611131-B1 | PYRAZOLOPYRIDINE DERIVATES | PALAU PHARMA SA (ES) | 2010-09-15 | — | — | EP | disclosed |
| US-7468376-B2 | Pyrazolopyridine derivates | PALAU PHARMA, S.A. (ES) | 2008-12-23 | — | — | US | disclosed |
| US-20060167040-A1 | Pyrazolopyridine derivates | J. URIACH Y COMPANIA S.A. (ES) | 2006-07-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060167040-A1 | Pyrazolopyridine derivates | MAPK1, MAP4K2, MAP4K3 | RIPK3 725/4885MAPK14 34/4885CSNK1D 75/4885 |
| US-20090005377-A1 | Pyrazolopyridine Derivates | MAPK1, MAPK4, MAP4K2 | RIPK3 689/4885MAPK14 33/4885CSNK1D 60/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.