Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 10/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 10/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2924235 | 0.93 | POLB (0.39) | GRM2ALDH1A1HCRTR1HCRTR2POLB | |
| SCHEMBL2926153 | 0.89 | HDAC7 (0.44) | HCRTR1HCRTR2POLBHDAC7 | |
| SCHEMBL2929656 | 0.89 | HCRTR2 (0.37) | HCRTR1HCRTR2POLB | |
| SCHEMBL2925061 | 0.89 | HCRTR2 (0.41) | SMN1; SMN2HCRTR1HCRTR2PDE4B | |
| SCHEMBL2924872 | 0.86 | HDAC7 (0.36) | HCRTR1HCRTR2POLBHDAC7 | |
| SCHEMBL2931971 | 0.85 | HCRTR1 (0.36) | GRM2HCRTR1HCRTR2 | |
| SCHEMBL2927512 | 0.84 | CYP46A1 (0.41) | HCRTR1HCRTR2POLB | |
| SCHEMBL3415826 | 0.84 | HCRTR1 (0.44) | ALDH1A1LMNATSHRHCRTR1HCRTR2 | |
| SCHEMBL2925286 | 0.84 | HCRTR1 (0.44) | ALDH1A1LMNATSHRHCRTR1HCRTR2 | |
| SCHEMBL2928983 | 0.84 | GRM2 (0.40) | GRM2LMNATSHRHTTHCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079690-B1 | 3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-09-15 | — | — | EP | disclosed |