Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 12/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 12/20 | 0.36 |
| ▸ | DPP4 | P27487 | 2/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2924236 | 0.95 | KDM1A (0.35) | HCRTR1HCRTR2 | |
| SCHEMBL2926155 | 0.90 | HDAC7 (0.43) | HCRTR1HCRTR2 | |
| SCHEMBL2925064 | 0.90 | HCRTR2 (0.43) | HCRTR1HCRTR2 | |
| SCHEMBL2929658 | 0.90 | HCRTR2 (0.36) | HCRTR1HCRTR2 | |
| SCHEMBL2929505 | 0.90 | HCRTR2 (0.43) | HCRTR1HCRTR2 | |
| SCHEMBL2924875 | 0.87 | HCRTR2 (0.37) | HCRTR1HCRTR2 | |
| SCHEMBL2927516 | 0.86 | CYP46A1 (0.40) | HCRTR1HCRTR2 | |
| SCHEMBL2928985 | 0.85 | GRM2 (0.35) | HCRTR1HCRTR2GRM2 | |
| SCHEMBL2931970 | 0.85 | GRM2 (0.37) | HCRTR1HCRTR2GRM2 | |
| SCHEMBL3415834 | 0.84 | HCRTR1 (0.46) | HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079690-B1 | 3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-09-15 | — | — | EP | disclosed |