⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23183040 | 0.87 | TSHR (0.33) | — | |
| SCHEMBL487300 | 0.86 | — | — | |
| SCHEMBL28508223 | 0.86 | — | — | |
| SCHEMBL14963993 | 0.85 | — | — | |
| SCHEMBL15187367 | 0.85 | — | — | |
| SCHEMBL487371 | 0.83 | USP2 (0.31) | — | |
| SCHEMBL202959 | 0.83 | USP2 (0.31) | — | |
| Ammonia Solution, Strong SCHEMBL28300155 | 0.83 | — | — | |
| SCHEMBL30945823 | 0.83 | — | — | |
| SCHEMBL210745 | 0.81 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240238423-A9 | TETRAHYDROISOQUINOLINE HETEROBIFUNCTIONAL BCL-XL DEGRADERS | Treeline Biosciences, Inc. | 2024-07-18 | — | — | US | disclosed |