Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 1/20 | 0.44 |
| ▸ | AKT2 | P31751 | 1/20 | 0.44 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.40 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 2/20 | 0.37 |
| ▸ | PIM1 | P11309 | 2/20 | 0.36 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18378727 | 0.82 | AKT1 (0.47) | AKT1AKT2PDK2LRRK2AURKA | |
| SCHEMBL17641537 | 0.82 | AKT2 (0.55) | AKT1AKT2PDK2LRRK2AURKA | |
| SCHEMBL20294499 | 0.81 | AKT2 (0.60) | AKT1AKT2PDK2LRRK2GPR35 | |
| SCHEMBL21451423 | 0.79 | IDO1 (0.53) | AKT1AKT2PDK2LRRK2ROCK2 | |
| SCHEMBL19726594 | 0.78 | AKT1 (0.43) | AKT1AKT2PDK2LRRK2AURKA | |
| SCHEMBL19589423 | 0.77 | ROCK2 (0.44) | AKT1AKT2ROCK2ROCK1 | |
| SCHEMBL18375564 | 0.77 | AKT1 (0.42) | AKT1AKT2PDK2LRRK2FEN1 | |
| SCHEMBL21172870 | 0.75 | CD274 (0.47) | ADRA1AMAPK1 | |
| SCHEMBL105445 | 0.74 | AKT1 (0.55) | AKT1AKT2PDK2LRRK2ADRA1D | |
| SCHEMBL15698609 | 0.72 | PDK2 (0.47) | AKT1AKT2PDK2LRRK2GPR35 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024148247-A2 | AZAINDAZOLES AS JAK2 INHIBITORS | AJAX THERAPEUTICS, INC. (US) | 2024-07-11 | — | — | WO | disclosed |