Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPEPPS | P55786 | 1/20 | 0.42 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.40 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PTGES | O14684 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.38 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27191722 | 0.88 | CYP11B1 (0.46) | NPEPPSTRPA1TRPM8KDM4EHTT | |
| SCHEMBL29326224 | 0.88 | NPEPPS (0.48) | NPEPPSTDP1KDM4EHTTFEN1 | |
| SCHEMBL29326363 | 0.84 | TNKS2 (0.50) | NPEPPSTDP1KDM4EHTTFEN1 | |
| SCHEMBL29326236 | 0.84 | NPEPPS (0.44) | NPEPPSTDP1KDM4EHTTFEN1 | |
| SCHEMBL29326279 | 0.83 | NPEPPS (0.42) | NPEPPSTRPA1TDP1KDM4EHTT | |
| SCHEMBL29326226 | 0.83 | NPEPPS (0.42) | NPEPPSTDP1KDM4EHTTFEN1 | |
| SCHEMBL29326666 | 0.83 | HSP90AA1 (0.43) | NPEPPSTDP1KDM4EHTTPTGES | |
| SCHEMBL29326273 | 0.82 | NPEPPS (0.41) | NPEPPSTDP1KDM4EHTTFEN1 | |
| SCHEMBL29326223 | 0.82 | FEN1 (0.58) | NPEPPSTDP1KDM4EHTTFEN1 | |
| SCHEMBL29326335 | 0.82 | NPEPPS (0.43) | NPEPPSTRPA1TDP1KDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240239807-A1 | SARS-COV2 MAIN PROTEASE INHIBITORS | GILEAD SCIENCES, INC. | 2024-07-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240239807-A1 | SARS-COV2 MAIN PROTEASE INHIBITORS | ACE2, TMPRSS2, ACE | NPEPPS 168/4885TRPA1 3385/4885TRPM8 2402/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.