Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.44 |
| ▸ | PTGES | O14684 | 6/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | METAP2 | P50579 | 1/20 | 0.36 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | PRKACA | P17612 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27378705 | 0.93 | TNKS2 (0.43) | TNKS2PTGESCYP2C9CYP3A4CYP2C19 | |
| SCHEMBL27192123 | 0.85 | TNKS2 (0.54) | TNKS2PTGESCYP2C9CYP3A4CYP2C19 | |
| SCHEMBL31018955 | 0.85 | TNKS2 (0.54) | TNKS2PTGESCYP2C9CYP3A4CYP2C19 | |
| SCHEMBL27378704 | 0.85 | TNKS2 (0.47) | TNKS2PTGESCYP2C9CYP3A4CYP2C19 | |
| SCHEMBL27191930 | 0.81 | TNKS2 (0.53) | TNKS2PTGESCYP2C9CYP3A4CYP2C19 | |
| SCHEMBL30702006 | 0.81 | TNKS2 (0.53) | TNKS2PTGESCYP2C9CYP3A4CYP2C19 | |
| SCHEMBL30701959 | 0.79 | CYP3A4 (0.43) | TNKS2PTGESCYP2C9CYP3A4CYP2C19 | |
| SCHEMBL27191803 | 0.79 | CYP3A4 (0.43) | TNKS2PTGESCYP2C9CYP3A4CYP2C19 | |
| SCHEMBL27191731 | 0.79 | TNKS2 (0.46) | TNKS2PTGESCYP2C9CYP3A4CYP2C19 | |
| SCHEMBL27378701 | 0.78 | ALDH1A1 (0.55) | TNKS2PTGESCYP2C9CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240239807-A1 | SARS-COV2 MAIN PROTEASE INHIBITORS | GILEAD SCIENCES, INC. | 2024-07-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240239807-A1 | SARS-COV2 MAIN PROTEASE INHIBITORS | ACE2, TMPRSS2, ACE | TNKS2 619/4885PTGES 1477/4885CYP2C9 263/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.