Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.38 |
| ▸ | CACNG8 | Q8WXS5 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | PTGES | O14684 | 3/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.35 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | KRAS | P01116 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27378771 | 0.89 | TNKS2 (0.40) | TNKS2KDM4EHTTTP53EGFR | |
| SCHEMBL29326522 | 0.84 | TNKS2 (0.46) | TNKS2KDM4EHTTPIK3C3 | |
| SCHEMBL29326555 | 0.82 | ERCC5 (0.36) | KDM4EHTTGRIA1CACNG8FEN1 | |
| SCHEMBL29326500 | 0.79 | TNKS2 (0.60) | TNKS2KDM4EHTTTP53FEN1 | |
| SCHEMBL29326563 | 0.78 | TNKS2 (0.56) | TNKS2KDM4EHTTTP53FEN1 | |
| SCHEMBL29326509 | 0.78 | TNKS2 (0.53) | TNKS2KDM4EHTTTP53FEN1 | |
| SCHEMBL29326363 | 0.78 | TNKS2 (0.50) | TNKS2KDM4EHTTTP53FEN1 | |
| SCHEMBL29326273 | 0.77 | NPEPPS (0.41) | TNKS2KDM4EHTTGRIA1CACNG8 | |
| SCHEMBL27378767 | 0.77 | CNR2 (0.42) | TNKS2KDM4EHTTPTGESCYP2C9 | |
| SCHEMBL29326503 | 0.76 | TNKS2 (0.55) | TNKS2KDM4EHTTTP53FEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240239807-A1 | SARS-COV2 MAIN PROTEASE INHIBITORS | GILEAD SCIENCES, INC. | 2024-07-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240239807-A1 | SARS-COV2 MAIN PROTEASE INHIBITORS | ACE2, TMPRSS2, ACE | TNKS2 619/4885KDM4E 3744/4885HTT 3577/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.