SCHEMBL29326599

SCHEMBL29326599

Cc1nc(Cl)nc2c1oc1ccc(-c3ccccc3)cc12

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PIM1 P11309 3/20 0.52
CSNK2A2 P19784 3/20 0.52
CSNK2B P67870 3/20 0.52
PIM3 Q86V86 3/20 0.52
PIM2 Q9P1W9 3/20 0.52
MEN1 O00255 4/20 0.44
KMT2A Q03164 4/20 0.44
L3MBTL1 Q9Y468 2/20 0.44
RXFP1 Q9HBX9 1/20 0.44
GAA P10253 1/20 0.44
ALDH1A1 P00352 4/20 0.40
MAPT P10636 4/20 0.40
KDM4E B2RXH2 3/20 0.40
HPGD P15428 2/20 0.40
TDP1 Q9NUW8 1/20 0.40
HRH4 Q9H3N8 1/20 0.39
PLA2G2A P14555 2/20 0.38
PLA2G4A P47712 2/20 0.38
TSHR P16473 1/20 0.37
LMNA P02545 3/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24388208 0.86 PIM1 (0.54) PIM1CSNK2A2CSNK2BPIM3PIM2
SCHEMBL29565166 0.86 PIM1 (0.54) PIM1CSNK2A2CSNK2BPIM3PIM2
SCHEMBL30493208 0.85 PIM1 (0.53) PIM1CSNK2A2CSNK2BPIM3PIM2
SCHEMBL24388223 0.85 PIM1 (0.53) PIM1CSNK2A2CSNK2BPIM3PIM2
SCHEMBL24388212 0.85 PIM1 (0.53) PIM1CSNK2A2CSNK2BPIM3PIM2
SCHEMBL23789519 0.83 PIM1 (0.39) PIM1CSNK2A2CSNK2BPIM3PIM2
SCHEMBL16922293 0.79 SMN1; SMN2 (0.45) PIM1CSNK2A2CSNK2BPIM3PIM2
SCHEMBL26819600 0.79 PIM1 (0.47) PIM1CSNK2A2CSNK2BPIM3PIM2
SCHEMBL24388410 0.78 PIM1 (0.47) PIM1CSNK2A2CSNK2BPIM3PIM2
SCHEMBL26819616 0.77 PIM1 (0.46) PIM1CSNK2A2CSNK2BPIM3PIM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4237506-B1 ORGANIC ELECTROLUMINESCENT DEVICE MERCK PATENT GMBH (DE) 2024-07-17 EP disclosed