Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 4/20 | 0.38 |
| ▸ | BTK | Q06187 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | PTGES | O14684 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | TNKS | O95271 | 1/20 | 0.37 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.37 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27379527 | 0.90 | HSD17B10 (0.42) | HSD17B10PKMKDM4EHTTALDH1A1 | |
| SCHEMBL29326426 | 0.86 | HSD17B10 (0.52) | HSD17B10PKMKDM4EHTTALDH1A1 | |
| SCHEMBL29326756 | 0.83 | HSD17B10 (0.58) | HSD17B10PKMKDM4EHTTALDH1A1 | |
| SCHEMBL29326311 | 0.81 | KDM4E (0.47) | KDM4EHTTGAAPTGESCYP2C9 | |
| SCHEMBL29326363 | 0.81 | TNKS2 (0.50) | KDM4EHTTGAAPTGESCYP2C9 | |
| SCHEMBL29326224 | 0.81 | NPEPPS (0.48) | HSD17B10PKMKDM4EHTTGAA | |
| SCHEMBL29326366 | 0.80 | KDM4E (0.47) | KDM4EHTTGAAPTGESCYP2C9 | |
| SCHEMBL29326321 | 0.79 | HSD17B10 (0.47) | HSD17B10PKMKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL29326236 | 0.79 | NPEPPS (0.44) | HSD17B10PKMKDM4EHTTGAA | |
| SCHEMBL29326676 | 0.79 | KDM4E (0.45) | KDM4EHTTSMN1; SMN2HPGDBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240239807-A1 | SARS-COV2 MAIN PROTEASE INHIBITORS | GILEAD SCIENCES, INC. | 2024-07-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240239807-A1 | SARS-COV2 MAIN PROTEASE INHIBITORS | ACE2, TMPRSS2, ACE | HSD17B10 433/4885PKM 2848/4885KDM4E 3744/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.