SCHEMBL2932779

SCHEMBL2932779

Cc1cccc(-c2ccccc2)c1.OBO

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.50
NPC1 O15118 1/20 0.50
HPGD P15428 1/20 0.50
RAB9A P51151 1/20 0.50
SMN1; SMN2 Q16637 1/20 0.50
ACHE P22303 3/20 0.48
POLB P06746 1/20 0.47
MAPT P10636 1/20 0.47
CTDSP1 Q9GZU7 1/20 0.47
PTPN5 P54829 1/20 0.47
CNR2 P34972 4/20 0.46
CNR1 P21554 3/20 0.46
DHODH Q02127 1/20 0.46
PPARG P37231 1/20 0.45
PPARA Q07869 1/20 0.45
AKR1C2 P52895 1/20 0.45
AKR1C1 Q04828 1/20 0.45
HSD17B1 P14061 1/20 0.45
HSD17B2 P37059 1/20 0.45
ENPP3 O14638 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Benzene SCHEMBL27980187 0.91 ACHE (0.58) TSHRNPC1HPGDRAB9ASMN1; SMN2
SCHEMBL29699277 0.91 ACHE (0.58) TSHRNPC1HPGDRAB9ASMN1; SMN2
SCHEMBL200730 0.91 ACHE (0.58) TSHRNPC1HPGDRAB9ASMN1; SMN2
SCHEMBL19503240 0.88 TSHR (0.55) TSHRNPC1HPGDRAB9ASMN1; SMN2
SCHEMBL28660662 0.88 TSHR (0.55) TSHRNPC1HPGDRAB9ASMN1; SMN2
SCHEMBL20689786 0.88 TSHR (0.55) TSHRNPC1HPGDRAB9ASMN1; SMN2
SCHEMBL28284301 0.88 TSHR (0.55) TSHRNPC1HPGDRAB9ASMN1; SMN2
Hydrogen Sulfide SCHEMBL27914332 0.88 TSHR (0.55) TSHRNPC1HPGDRAB9ASMN1; SMN2
Bicarbonate SCHEMBL28836750 0.86 POLB (0.56) TSHRNPC1HPGDRAB9ASMN1; SMN2
Hydrochloric Acid SCHEMBL598365 0.86 TSHR (0.53) TSHRNPC1HPGDRAB9ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2021330-B1 BENZIMIDAZOLE MODULATORS OF VR1 JANSSEN PHARMACEUTICA NV (BE) 2010-09-22 EP disclosed
EP-2021330-A2 BENZIMIDAZOLE MODULATORS OF VR1 Janssen Pharmaceutica, N.V. (BE) 2009-02-11 EP disclosed
WO-2007130780-A2 BENZIMIDAZOLE MODULATORS OF VR1 JANSSEN PHARMACEUTICA N.V. (BE) 2007-11-15 WO disclosed