SCHEMBL29328887

SCHEMBL29328887

N#Cc1cc(OC2CCN(CC(F)(F)F)CC2)cc(Nc2ccc3cc[nH]c3c2)n1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CSF1R P07333 1/20 0.39
FLT3 P36888 1/20 0.39
SGK1 O00141 3/20 0.38
PRKCQ Q04759 3/20 0.36
HTR7 P34969 3/20 0.36
ADRA1B P35368 1/20 0.36
PRKCD Q05655 1/20 0.36
P2RX3 P56373 2/20 0.35
P2RX2 Q9UBL9 2/20 0.35
HRH3 Q9Y5N1 1/20 0.35
IKBKE Q14164 1/20 0.35
TBK1 Q9UHD2 1/20 0.35
JAK2 O60674 2/20 0.34
JAK1 P23458 2/20 0.34
SYK P43405 1/20 0.34
HTR1A P08908 2/20 0.34
HTR5A P47898 2/20 0.34
HTR1D P28221 1/20 0.34
HTR1B P28222 1/20 0.34
HTR2A P28223 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29329002 0.83 SYK (0.38) PRKCQSYK
SCHEMBL24539078 0.82 EGFR (0.37) PRKCQPRKCDSYK
SCHEMBL29745872 0.82 EGFR (0.37) PRKCQPRKCDSYK
SCHEMBL29329119 0.81 PRKCQ (0.38) PRKCQPRKCDJAK2SYKCHRNA7
SCHEMBL29331087 0.78 PRKCQ (0.36) PRKCQHRH3SYKCHRNA7
SCHEMBL29329004 0.78 PRKCQ (0.38) PRKCQPRKCDJAK2SYK
SCHEMBL29328882 0.78 SCN9A (0.36) PRKCQPRKCDSYKCHRNA7
SCHEMBL30629380 0.77 PRKCQ (0.39) PRKCQHRH3SYKCHRNA7
SCHEMBL24539065 0.77 PRKCQ (0.39) PRKCQHRH3SYKCHRNA7
SCHEMBL29329642 0.76 ABL1 (0.46) PRKCQSYK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024151919-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY IFM DUE, INC. (US) 2024-07-18 WO disclosed