Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 2/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2931339 | 0.89 | CRHR1 (0.52) | CRHR1CRHR2HSD17B10LMNAMAPK1 | |
| SCHEMBL2182127 | 0.86 | CRHR1 (0.61) | CRHR1CRHR2HSD17B10LMNAMAPK1 | |
| SCHEMBL2496095 | 0.86 | CRHR1 (0.49) | CRHR1CRHR2HSD17B10LMNAMAPK1 | |
| SCHEMBL2494849 | 0.85 | CRHR1 (0.48) | CRHR1CRHR2HSD17B10LMNAMAPK1 | |
| SCHEMBL2933954 | 0.84 | HPGD (0.34) | CRHR1CRHR2HSD17B10LMNAMAPK1 | |
| SCHEMBL2933952 | 0.84 | HPGD (0.34) | CRHR1CRHR2HSD17B10LMNAMAPK1 | |
| SCHEMBL2495432 | 0.83 | POLB (0.40) | CRHR1LMNAKMT2APOLBMEN1 | |
| SCHEMBL2498882 | 0.82 | POLB (0.39) | CRHR1LMNAKMT2APOLBMEN1 | |
| SCHEMBL29430976 | 0.81 | CRHR1 (0.57) | CRHR1CRHR2HSD17B10LMNAMAPK1 | |
| SCHEMBL2495462 | 0.81 | KDM4E (0.38) | CRHR1HSD17B10LMNAKMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094709-B1 | THIAZOLE PYRAZOLOPYRIMIDINES AS CRF1 RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2010-09-15 | — | — | EP | disclosed |